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    selt-1.1 Thioredoxin reductase-like selenoprotein T homolog selt-1.1 [ Caenorhabditis elegans ]

    Gene ID: 181343, updated on 2-Nov-2024

    Summary

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    Official Symbol
    selt-1.1
    Official Full Name
    Thioredoxin reductase-like selenoprotein T homolog selt-1.1
    Primary source
    WormBase:WBGene00007955
    Locus tag
    CELE_C35C5.3
    See related
    AllianceGenome:WB:WBGene00007955
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Predicted to enable thioredoxin-disulfide reductase (NADPH) activity. Predicted to be involved in cell redox homeostasis. Predicted to be located in endoplasmic reticulum. Predicted to be active in endoplasmic reticulum membrane. Is expressed in several structures, including P5.paaa; amphid neurons; body wall musculature; epithelial cell; and pharyngeal cell. Orthologous to human SELENOT (selenoprotein T). [provided by Alliance of Genome Resources, Nov 2024]
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    Genomic context

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    See selt-1.1 in Genome Data Viewer
    Location:
    chromosome: X
    Exon count:
    5
    Sequence:
    Chromosome: X; NC_003284.9 (11545047..11546495, complement)

    Chromosome X - NC_003284.9Genomic Context describing neighboring genes Neighboring gene N-acetylated-alpha-linked acidic dipeptidase 2 Neighboring gene ncRNA Neighboring gene pseudo Neighboring gene Ras-related C3 botulinum toxin substrate 1;Signal recognition particle protein Neighboring gene ncRNA

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003284.9

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Selenoprotein T is required for pathogenic bacteria avoidance in Caenorhabditis elegans. Romanelli-Cedrez L, et al. Free Radic Biol Med, 2017 Jul. PMID 28347729
    2. A map of the interactome network of the metazoan C. elegans. Li S, et al. Science, 2004 Jan 23. PMID 14704431, Free PMC Article
    3. EPIC: software toolkit for elution profile-based inference of protein complexes. Hu LZ, et al. Nat Methods, 2019 Aug. PMID 31308550, Free PMC Article
    4. OrthoList: a compendium of C. elegans genes with human orthologs. Shaye DD, et al. PLoS One, 2011. PMID 21647448, Free PMC Article
    5. OrthoList 2: A New Comparative Genomic Analysis of Human and Caenorhabditis elegans Genes. Kim W, et al. Genetics, 2018 Oct. PMID 30120140, Free PMC Article

    See all (6) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. this study shows that selenoprotein T is required for pathogenic bacteria avoidance in Caenorhabditis elegans
      Title: Selenoprotein T is required for pathogenic bacteria avoidance in Caenorhabditis elegans.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables oxidoreductase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables thioredoxin-disulfide reductase (NADPH) activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables thioredoxin-disulfide reductase (NADPH) activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in cell redox homeostasis IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in cellular oxidant detoxification IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in endoplasmic reticulum IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in endoplasmic reticulum membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    Thioredoxin reductase-like selenoprotein T homolog selt-1.1
    NP_509929.2
    • Confirmed by transcript evidence
    NP_509930.2
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003284.9 Reference assembly

      Range
      11545047..11546495 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_077529.5 → NP_509930.2  Thioredoxin reductase-like selenoprotein T homolog selt-1.1 [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_509930.2

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q9U3N5
      Conserved Domains (1) summary
      cl01407
      Location:84 → 222
      Rdx; Rdx family

    2. NM_077528.4 → NP_509929.2  Thioredoxin reductase-like selenoprotein T homolog selt-1.1 [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_509929.2

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q93327, Q9U3N5
      Conserved Domains (1) summary
      cl01407
      Location:87 → 225
      Rdx; Rdx family
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9U3N5.2

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