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    hira-1 Protein HIRA;Protein HIRA-like C-terminal domain-containing protein [ Caenorhabditis elegans ]

    Gene ID: 175709, updated on 2-Nov-2024

    Summary

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    Official Symbol
    hira-1
    Official Full Name
    Protein HIRA;Protein HIRA-like C-terminal domain-containing protein
    Primary source
    WormBase:WBGene00019627
    Locus tag
    CELE_K10D2.1
    See related
    AllianceGenome:WB:WBGene00019627
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Predicted to contribute to nucleosome binding activity. Predicted to be involved in chromatin remodeling. Predicted to be located in chromatin. Predicted to be part of HIR complex. Is expressed widely. Used to study chromosome 22q11.2 deletion syndrome, distal. Orthologous to human HIRA (histone cell cycle regulator). [provided by Alliance of Genome Resources, Nov 2024]
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    Genomic context

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    See hira-1 in Genome Data Viewer
    Location:
    chromosome: III
    Exon count:
    10
    Sequence:
    Chromosome: III; NC_003281.10 (5191124..5196088)

    Chromosome III - NC_003281.10Genomic Context describing neighboring genes Neighboring gene PAP-associated domain-containing protein Neighboring gene Protein phosphatase 1 regulatory subunit 7 Neighboring gene Molybdopterin synthase sulfur carrier subunit Neighboring gene NADPH--cytochrome P450 reductase Neighboring gene ATPase morc-1

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003281.10

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. H3.3 Nucleosome Assembly Mutants Display a Late-Onset Maternal Effect. Burkhart KB, et al. Curr Biol, 2020 Jun 22. PMID 32470364, Free PMC Article
    2. A transcriptional cofactor regulatory network for the C. elegans intestine. Horowitz BB, et al. G3 (Bethesda), 2023 Jul 5. PMID 37119809, Free PMC Article
    3. A global analysis of genetic interactions in Caenorhabditis elegans. Byrne AB, et al. J Biol, 2007. PMID 17897480, Free PMC Article
    4. A modified TurboID approach identifies tissue-specific centriolar components in C. elegans. Holzer E, et al. PLoS Genet, 2022 Apr. PMID 35442950, Free PMC Article
    5. Novel LOTUS-domain proteins are organizational hubs that recruit C. elegans Vasa to germ granules. Cipriani PG, et al. Elife, 2021 Jul 5. PMID 34223818, Free PMC Article

    See all (9) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    contributes_to nucleosome binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in DNA-templated transcription IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in chromatin organization IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in chromatin remodeling IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in chromatin remodeling IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in regulation of DNA-templated transcription IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    part_of HIR complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in chromatin IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    Protein HIRA;Protein HIRA-like C-terminal domain-containing protein
    NP_001343798.1
    • Confirmed by transcript evidence
    NP_498101.2
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003281.10 Reference assembly

      Range
      5191124..5196088
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_065700.7 → NP_498101.2  Protein HIRA [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_498101.2

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      C4ALD2, Q09589, Q8IG07
      Conserved Domains (4) summary
      COG2319
      Location:10 → 359
      WD40; WD40 repeat [General function prediction only]
      pfam07569
      Location:688 → 877
      Hira; TUP1-like enhancer of split
      sd00039
      Location:79 → 131
      7WD40; WD40 repeat [structural motif]
      cl02567
      Location:10 → 351
      WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...

    2. NM_001356742.3 → NP_001343798.1  Protein HIRA-like C-terminal domain-containing protein [Caenorhabditis elegans]

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A2C9C364
      Conserved Domains (1) summary
      pfam07569
      Location:256 → 438
      Hira; TUP1-like enhancer of split

    RNA

    1. NR_151567.1 RNA Sequence

      Status: REVIEWED

    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q09589.2

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