argn-1 Arginase [Caenorhabditis elegans] - Gene

Summary

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Official Symbol: argn-1
Official Full Name: Arginase
Primary source: WormBase:WBGene00020658
Locus tag: CELE_T21F4.1
See related: AllianceGenome:WB:WBGene00020658
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Caenorhabditis elegans (strain: Bristol N2)
Lineage: Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary: Predicted to enable arginase activity and manganese ion binding activity. Involved in innate immune response. Predicted to be active in cytosol. Is expressed in hypodermal cell. Used to study hyperargininemia. Human ortholog(s) of this gene implicated in asthma; hepatocellular carcinoma; and hyperargininemia. Orthologous to human ARG1 (arginase 1) and ARG2 (arginase 2). [provided by Alliance of Genome Resources, Dec 2024]
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Genomic context

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See argn-1 in Genome Data Viewer

Location:: chromosome: X

Exon count:: 6

Sequence:: Chromosome: X; NC_003284.9 (5630023..5631825)

Chromosome X - NC_003284.9 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_003284.9

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Defective arginine metabolism impairs mitochondrial homeostasis in Caenorhabditiselegans.
Title: Defective arginine metabolism impairs mitochondrial homeostasis in Caenorhabditiselegans.

Submit: New GeneRIF Correction

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

T21F4.1 (e-PCR)
- UniSTS:315045

Homology

Orthologs from OrthoDB

Gene Ontology Provided by WormBase

Function	Evidence Code	Pubs
enables arginase activity	IBA Inferred from Biological aspect of Ancestor more info
enables manganese ion binding	IBA Inferred from Biological aspect of Ancestor more info
enables metal ion binding	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in arginine catabolic process to ornithine	IBA Inferred from Biological aspect of Ancestor more info
involved_in arginine metabolic process	IEA Inferred from Electronic Annotation more info
involved_in innate immune response	HEP more info	PubMed
involved_in urea cycle	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
is_active_in cytosol	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: Arginase

NP_001370979.1

Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_003284.9 Reference assembly

Range

5630023..5631825

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_001383585.1 → NP_001370979.1 Arginase [Caenorhabditis elegans]

Status: REVIEWED

UniProtKB/TrEMBL

A0A1X7RC97

Conserved Domains (1) summary

cd09989
Location:12 → 296

Arginase; Arginase family