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    teg-4 Splicing factor 3B subunit 3 [ Caenorhabditis elegans ]

    Gene ID: 172406, updated on 2-Nov-2024

    Summary

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    Official Symbol
    teg-4
    Official Full Name
    Splicing factor 3B subunit 3
    Primary source
    WormBase:WBGene00019323
    Locus tag
    CELE_K02F2.3
    See related
    AllianceGenome:WB:WBGene00019323
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Predicted to enable U2 snRNA binding activity. Predicted to be involved in mRNA splicing, via spliceosome. Predicted to be part of U2 snRNP. Predicted to be active in nucleus. Orthologous to human SF3B3 (splicing factor 3b subunit 3). [provided by Alliance of Genome Resources, Nov 2024]
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    Genomic context

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    See teg-4 in Genome Data Viewer
    Location:
    chromosome: I
    Exon count:
    22
    Sequence:
    Chromosome: I; NC_003279.8 (6814511..6834699)

    Chromosome I - NC_003279.8Genomic Context describing neighboring genes Neighboring gene Conserved secreted protein Neighboring gene ncRNA Neighboring gene Ubiquitin-like protease family profile domain-containing protein Neighboring gene G-protein coupled receptors family 1 profile domain-containing protein Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene Adenosylhomocysteinase

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003279.8

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. TEG-1 CD2BP2 regulates stem cell proliferation and sex determination in the C. elegans germ line and physically interacts with the UAF-1 U2AF65 splicing factor. Wang C, et al. Dev Dyn, 2012 Mar. PMID 22275078, Free PMC Article
    2. A mutation in teg-4, which encodes a protein homologous to the SAP130 pre-mRNA splicing factor, disrupts the balance between proliferation and differentiation in the C. elegans germ line. Mantina P, et al. Mech Dev, 2009 May-Jun. PMID 19368799
    3. Genetic and molecular analysis of the dpy-14 region in Caenorhabditis elegans. McKim KS, et al. Mol Gen Genet, 1992 May. PMID 1603066
    4. Genetic analysis of sterile mutants in the dpy-5 unc-13 (I) genomic region of Caenorhabditis elegans. McDowall JS, et al. Mol Gen Genet, 1997 Jun. PMID 9230900
    5. H3K4me2 regulates the recovery of protein biosynthesis and homeostasis following DNA damage. Wang S, et al. Nat Struct Mol Biol, 2020 Dec. PMID 33046905

    See all (22) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. A reduction in teg-4 activity reduces the splicing efficiency of targets involved in controlling the balance between proliferation and differentiation.
      Title: A mutation in teg-4, which encodes a protein homologous to the SAP130 pre-mRNA splicing factor, disrupts the balance between proliferation and differentiation in the C. elegans germ line.
    Submit: New GeneRIF Correction

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables U2 snRNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables nucleic acid binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in mRNA splicing, via spliceosome IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    part_of U2 snRNP IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    Splicing factor 3B subunit 3
    NP_491953.1
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003279.8 Reference assembly

      Range
      6814511..6834699
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_059552.4 → NP_491953.1  Splicing factor 3B subunit 3 [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_491953.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      O44985
      Conserved Domains (2) summary
      pfam03178
      Location:857 → 1185
      CPSF_A; CPSF A subunit region
      pfam10433
      Location:77 → 591
      MMS1_N; Mono-functional DNA-alkylating methyl methanesulfonate N-term
    Nucleotide Protein
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