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    gbf-1 Golgi-specific brefeldin A-resistance guanine nucleotide exchange factor 1 homolog [ Caenorhabditis elegans ]

    Gene ID: 176609, updated on 9-Dec-2024

    Summary

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    Official Symbol
    gbf-1
    Official Full Name
    Golgi-specific brefeldin A-resistance guanine nucleotide exchange factor 1 homolog
    Primary source
    WormBase:WBGene00007703
    Locus tag
    CELE_C24H11.7
    See related
    AllianceGenome:WB:WBGene00007703
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Predicted to enable guanyl-nucleotide exchange factor activity. Involved in several processes, including endoplasmic reticulum organization; endosomal transport; and mitochondrion organization. Located in Golgi cis cisterna and endoplasmic reticulum exit site. Human ortholog(s) of this gene implicated in Charcot-Marie-Tooth disease dominant intermediate A. Orthologous to human GBF1 (golgi brefeldin A resistant guanine nucleotide exchange factor 1). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See gbf-1 in Genome Data Viewer
    Location:
    chromosome: III
    Exon count:
    22
    Sequence:
    Chromosome: III; NC_003281.10 (11751258..11773681, complement)

    Chromosome III - NC_003281.10Genomic Context describing neighboring genes Neighboring gene ncRNA Neighboring gene Cell cycle checkpoint protein RAD1 homolog mrt-2 Neighboring gene Peptidase S26 domain-containing protein Neighboring gene Mediator of RNA polymerase II transcription subunit 21

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003281.10

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Correction: Serum- and Glucocorticoid-Inducible Kinase-1 (SGK-1) Plays a Role in Membrane Trafficking in Caenorhabditis elegans. Zhu M, et al. PLoS One, 2016. PMID 27631731, Free PMC Article
    2. Multiple checkpoints of protein clearance machinery are modulated by a common microRNA, miR-4813-3p, through its putative target genes: Studies employing transgenic C. elegans model. Sarkar A, et al. Biochim Biophys Acta Mol Cell Res, 2022 Dec. PMID 35998789
    3. The ArfGEF GBF-1 Is Required for ER Structure, Secretion and Endocytic Transport in C. elegans. Ackema KB, et al. PLoS One, 2013. PMID 23840591, Free PMC Article
    4. Serum- and Glucocorticoid-Inducible Kinase-1 (SGK-1) Plays a Role in Membrane Trafficking in Caenorhabditis elegans. Zhu M, et al. PLoS One, 2015. PMID 26115433, Free PMC Article
    5. The small GTPase Arf1 modulates mitochondrial morphology and function. Ackema KB, et al. EMBO J, 2014 Nov 18. PMID 25190516, Free PMC Article

    See all (13) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables guanyl-nucleotide exchange factor activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in cellular localization IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in endoplasmic reticulum organization IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in endosomal transport IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in mitochondrion organization IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in regulation of ARF protein signal transduction IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in secretion IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in vesicle-mediated transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in Golgi apparatus IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in Golgi cis cisterna IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in endomembrane system IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in endoplasmic reticulum exit site IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in endoplasmic reticulum-Golgi intermediate compartment IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in intracellular membrane-bounded organelle IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    Golgi-specific brefeldin A-resistance guanine nucleotide exchange factor 1 homolog
    NP_001366879.1
    • Confirmed by transcript evidence
    NP_001368124.1
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003281.10 Reference assembly

      Range
      11751258..11773681 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001379938.2 → NP_001366879.1  Golgi-specific brefeldin A-resistance guanine nucleotide exchange factor 1 homolog [Caenorhabditis elegans]

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      G5EGS5, H8ESE7
      Conserved Domains (3) summary
      PLN03209
      Location:1696 → 1810
      PLN03209; translocon at the inner envelope of chloroplast subunit 62; Provisional
      COG5307
      Location:354 → 998
      COG5307; Guanine-nucleotide exchange factor, contains Sec7 domain [General function prediction only]
      pfam01369
      Location:631 → 814
      Sec7; Sec7 domain

    2. NM_001379939.1 → NP_001368124.1  Golgi-specific brefeldin A-resistance guanine nucleotide exchange factor 1 homolog [Caenorhabditis elegans]

      Status: REVIEWED

      Conserved Domains (1) summary
      PHA03247
      Location:211 → 475
      PHA03247; large tegument protein UL36; Provisional
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    G5EGS5.1

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