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    dpm-3 putative dolichol-phosphate mannosyltransferase subunit 3 [ Caenorhabditis elegans ]

    Gene ID: 178189, updated on 2-Nov-2024

    Summary

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    Official Symbol
    dpm-3
    Official Full Name
    putative dolichol-phosphate mannosyltransferase subunit 3
    Primary source
    WormBase:WBGene00009219
    Locus tag
    CELE_F28D1.11
    See related
    AllianceGenome:WB:WBGene00009219
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Predicted to be involved in GPI anchor biosynthetic process. Predicted to be located in endoplasmic reticulum and membrane. Predicted to be part of dolichol-phosphate-mannose synthase complex. Predicted to be active in endoplasmic reticulum membrane. Human ortholog(s) of this gene implicated in congenital disorder of glycosylation type I and muscular dystrophy-dystroglycanopathy type B15. Orthologous to human DPM3 (dolichyl-phosphate mannosyltransferase subunit 3, regulatory). [provided by Alliance of Genome Resources, Nov 2024]
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    Genomic context

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    See dpm-3 in Genome Data Viewer
    Location:
    chromosome: IV
    Exon count:
    3
    Sequence:
    Chromosome: IV; NC_003282.8 (12391587..12392120)

    Chromosome IV - NC_003282.8Genomic Context describing neighboring genes Neighboring gene Ig-like domain-containing protein Neighboring gene ncRNA Neighboring gene Small ribosomal subunit protein uS12 Neighboring gene Long-chain-fatty-acid--CoA ligase Neighboring gene ncRNA Neighboring gene ncRNA

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003282.8

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. RNAi screening of human glycogene orthologs in the nematode Caenorhabditis elegans and the construction of the C. elegans glycogene database. Akiyoshi S, et al. Glycobiology, 2015 Jan. PMID 25091817, Free PMC Article
    2. Amino acid and protein specificity of protein fatty acylation in C. elegans. Zhang B, et al. Proc Natl Acad Sci U S A, 2024 Jan 30. PMID 38252833, Free PMC Article
    3. OrthoList: a compendium of C. elegans genes with human orthologs. Shaye DD, et al. PLoS One, 2011. PMID 21647448, Free PMC Article
    4. OrthoList 2: A New Comparative Genomic Analysis of Human and Caenorhabditis elegans Genes. Kim W, et al. Genetics, 2018 Oct. PMID 30120140, Free PMC Article
    5. Genome sequence of the nematode C. elegans: a platform for investigating biology. C. elegans Sequencing Consortium. Science, 1998 Dec 11. PMID 9851916

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by WormBase

    Process Evidence Code Pubs
    involved_in GPI anchor biosynthetic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in protein glycosylation IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    part_of dolichol-phosphate-mannose synthase complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in endoplasmic reticulum IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in endoplasmic reticulum membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in endoplasmic reticulum membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    putative dolichol-phosphate mannosyltransferase subunit 3
    NP_502366.1
    • Partially confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003282.8 Reference assembly

      Range
      12391587..12392120
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_069965.4 → NP_502366.1  putative dolichol-phosphate mannosyltransferase subunit 3 [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_502366.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q9XVV5
      Conserved Domains (1) summary
      pfam08285
      Location:10 → 91
      DPM3; Dolichol-phosphate mannosyltransferase subunit 3 (DPM3)
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9XVV5.1

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