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    scl-12 SCP domain-containing protein [ Caenorhabditis elegans ]

    Gene ID: 186714, updated on 2-Nov-2024

    Summary

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    Official Symbol
    scl-12
    Official Full Name
    SCP domain-containing protein
    Primary source
    WormBase:WBGene00019178
    Locus tag
    CELE_H10D18.2
    See related
    AllianceGenome:WB:WBGene00019178
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Predicted to be active in extracellular space. Orthologous to several human genes including PI15 (peptidase inhibitor 15). [provided by Alliance of Genome Resources, Nov 2024]
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    Genomic context

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    See scl-12 in Genome Data Viewer
    Location:
    chromosome: V
    Exon count:
    4
    Sequence:
    Chromosome: V; NC_003283.11 (3812591..3813437)

    Chromosome V - NC_003283.11Genomic Context describing neighboring genes Neighboring gene G-protein coupled receptors family 1 profile domain-containing protein Neighboring gene SCP domain-containing protein Neighboring gene FERM domain-containing protein;SCP domain-containing protein Neighboring gene Retrotransposon gag protein Neighboring gene pseudo

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003283.11

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Mobilization of cholesterol induces the transition from quiescence to growth in Caenorhabditis elegans through steroid hormone and mTOR signaling. Schmeisser K, et al. Commun Biol, 2024 Jan 24. PMID 38267699, Free PMC Article
    2. Conservation of caspase substrates across metazoans suggests hierarchical importance of signaling pathways over specific targets and cleavage site motifs in apoptosis. Crawford ED, et al. Cell Death Differ, 2012 Dec. PMID 22918439, Free PMC Article
    3. OrthoList: a compendium of C. elegans genes with human orthologs. Shaye DD, et al. PLoS One, 2011. PMID 21647448, Free PMC Article
    4. OrthoList 2: A New Comparative Genomic Analysis of Human and Caenorhabditis elegans Genes. Kim W, et al. Genetics, 2018 Oct. PMID 30120140, Free PMC Article
    5. Genome sequence of the nematode C. elegans: a platform for investigating biology. C. elegans Sequencing Consortium. Science, 1998 Dec 11. PMID 9851916

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by WormBase

    Component Evidence Code Pubs
    is_active_in extracellular space IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    SCP domain-containing protein
    NP_504056.1
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003283.11 Reference assembly

      Range
      3812591..3813437
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_071655.3 → NP_504056.1  SCP domain-containing protein [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_504056.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q9N5N3
      Conserved Domains (1) summary
      smart00198
      Location:21 → 175
      SCP; SCP / Tpx-1 / Ag5 / PR-1 / Sc7 family of extracellular domains
    Nucleotide Protein
    Heading Accession and Version

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