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    rga-3 Rho-GAP domain-containing protein [ Caenorhabditis elegans ]

    Gene ID: 178961, updated on 9-Dec-2024

    Summary

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    Official Symbol
    rga-3
    Official Full Name
    Rho-GAP domain-containing protein
    Primary source
    WormBase:WBGene00019600
    Locus tag
    CELE_K09H11.3
    See related
    AllianceGenome:WB:WBGene00019600
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Enables GTPase activator activity. Involved in asymmetric protein localization involved in cell fate determination; cortical actin cytoskeleton organization; and regulation of actin filament-based process. Located in cell cortex and centrosome. Is expressed in embryonic cell; germ line; and pharyngeal muscle cell. Orthologous to human ARHGAP11A (Rho GTPase activating protein 11A). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See rga-3 in Genome Data Viewer
    Location:
    chromosome: V
    Exon count:
    9
    Sequence:
    Chromosome: V; NC_003283.11 (5717885..5722089)

    Chromosome V - NC_003283.11Genomic Context describing neighboring genes Neighboring gene Aminomethyltransferase Neighboring gene Neuropeptide CCHamide-1 Neighboring gene ncRNA Neighboring gene Filaggrin Neighboring gene ncRNA Neighboring gene pseudo

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003283.11

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Novel cytokinetic ring components drive negative feedback in cortical contractility. Bell KR, et al. Mol Biol Cell, 2020 Jul 15. PMID 32491957, Free PMC Article
    2. OSGN-1 is a conserved flavin-containing monooxygenase required to stabilize the intercellular bridge in late cytokinesis. Goupil E, et al. Proc Natl Acad Sci U S A, 2024 Mar 12. PMID 38442170, Free PMC Article
    3. Anisotropies in cortical tension reveal the physical basis of polarizing cortical flows. Mayer M, et al. Nature, 2010 Sep 30. PMID 20852613
    4. A conserved RhoGAP limits M phase contractility and coordinates with microtubule asters to confine RhoA during cytokinesis. Zanin E, et al. Dev Cell, 2013 Sep 16. PMID 24012485, Free PMC Article
    5. Functions of the novel RhoGAP proteins RGA-3 and RGA-4 in the germ line and in the early embryo of C. elegans. Schmutz C, et al. Development, 2007 Oct. PMID 17728351

    See all (18) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. identified two redundant GTPase activating proteins (GAPs) - RGA-3 and RGA-4 - that regulate Rho GTPase function at the plasma membrane in early embryos
      Title: Functions of the novel RhoGAP proteins RGA-3 and RGA-4 in the germ line and in the early embryo of C. elegans.
    2. we identify the GTPase-activating proteins (GAPs) RGA-3 which regulate the activity of the small GTPase RHO-1
      Title: The Rho GTPase-activating proteins RGA-3 and RGA-4 are required to set the initial size of PAR domains in Caenorhabditis elegans one-cell embryos.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables GTPase activator activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables GTPase activator activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables GTPase activator activity IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in asymmetric protein localization involved in cell fate determination IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in cortical actin cytoskeleton organization IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in regulation of actin filament-based process IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in regulation of actin filament-based process IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in signal transduction IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in cell cortex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in centrosome IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    Rho-GAP domain-containing protein
    NP_504503.1
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003283.11 Reference assembly

      Range
      5717885..5722089
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_072102.4 → NP_504503.1  Rho-GAP domain-containing protein [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_504503.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      O01585
      Conserved Domains (1) summary
      smart00324
      Location:63 → 232
      RhoGAP; GTPase-activator protein for Rho-like GTPases
    Nucleotide Protein
    Heading Accession and Version

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