pcbd-1 Putative pterin-4-alpha-carbinolamine dehydratase [Caenorhabditis elegans] - Gene

Summary

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Official Symbol: pcbd-1
Official Full Name: Putative pterin-4-alpha-carbinolamine dehydratase
Primary source: WormBase:WBGene00020397
Locus tag: CELE_T10B11.1
See related: AllianceGenome:WB:WBGene00020397
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Caenorhabditis elegans (strain: Bristol N2)
Lineage: Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary: Predicted to enable 4-alpha-hydroxytetrahydrobiopterin dehydratase activity. Predicted to be involved in tetrahydrobiopterin biosynthetic process. Is expressed in head; hypodermis; neurons; and pharyngeal muscle cell. Human ortholog(s) of this gene implicated in BH4-deficient hyperphenylalaninemia D. Orthologous to several human genes including PCBD1 (pterin-4 alpha-carbinolamine dehydratase 1). [provided by Alliance of Genome Resources, Nov 2024]
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Genomic context

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See pcbd-1 in Genome Data Viewer

Location:: chromosome: I

Exon count:: 3

Sequence:: Chromosome: I; NC_003279.8 (6951135..6951982)

Chromosome I - NC_003279.8 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_003279.8

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

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Pathways from PubChem

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

T10B11.1 (e-PCR)
- UniSTS:321059

Homology

Orthologs from OrthoDB

Gene Ontology Provided by WormBase

Function	Evidence Code	Pubs
enables 4-alpha-hydroxytetrahydrobiopterin dehydratase activity	IBA Inferred from Biological aspect of Ancestor more info
enables 4-alpha-hydroxytetrahydrobiopterin dehydratase activity	IEA Inferred from Electronic Annotation more info
enables lyase activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in tetrahydrobiopterin biosynthetic process	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: Putative pterin-4-alpha-carbinolamine dehydratase

NP_491982.2

Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

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Reference assembly

Genomic

NC_003279.8 Reference assembly

Range

6951135..6951982

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_059581.8 → NP_491982.2 Putative pterin-4-alpha-carbinolamine dehydratase [Caenorhabditis elegans]

See identical proteins and their annotated locations for NP_491982.2

Status: REVIEWED

UniProtKB/Swiss-Prot

Q9TZH6

Conserved Domains (1) summary

cd00914
Location:64 → 139

PCD_DCoH_subfamily_b; PCD_DCoH: The bifunctional protein pterin-4alpha-carbinolamine dehydratase (PCD), also known as DCoH (dimerization cofactor of hepatocyte nuclear factor-1), is both a transcription activator and a metabolic enzyme. DCoH stimulates gene expression by ...