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    dnj-15 J domain-containing protein [ Caenorhabditis elegans ]

    Gene ID: 187149, updated on 9-Dec-2024

    Summary

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    Official Symbol
    dnj-15
    Official Full Name
    J domain-containing protein
    Primary source
    WormBase:WBGene00001033
    Locus tag
    CELE_K08D10.2
    See related
    AllianceGenome:WB:WBGene00001033
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Predicted to enable ATPase activator activity and protein-folding chaperone binding activity. Predicted to be involved in [2Fe-2S] cluster assembly. Predicted to be active in mitochondrion. Human ortholog(s) of this gene implicated in sideroblastic anemia. Orthologous to human HSCB (HscB mitochondrial iron-sulfur cluster cochaperone). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See dnj-15 in Genome Data Viewer
    Location:
    chromosome: IV
    Exon count:
    4
    Sequence:
    Chromosome: IV; NC_003282.8 (4176388..4178364)

    Chromosome IV - NC_003282.8Genomic Context describing neighboring genes Neighboring gene RRM domain-containing protein Neighboring gene RRM domain-containing protein Neighboring gene tRNA-intron lyase;tRNA_int_endo domain-containing protein Neighboring gene Uncharacterized protein Neighboring gene pseudo

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003282.8

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Caenorhabditis elegans as a model system to study intercompartmental proteostasis: Interrelation of mitochondrial function, longevity, and neurodegenerative diseases. Kirstein-Miles J, et al. Dev Dyn, 2010 May. PMID 20419784, Free PMC Article
    2. Identification of genes that protect the C. elegans genome against mutations by genome-wide RNAi. Pothof J, et al. Genes Dev, 2003 Feb 15. PMID 12600937, Free PMC Article
    3. OrthoList: a compendium of C. elegans genes with human orthologs. Shaye DD, et al. PLoS One, 2011. PMID 21647448, Free PMC Article
    4. OrthoList 2: A New Comparative Genomic Analysis of Human and Caenorhabditis elegans Genes. Kim W, et al. Genetics, 2018 Oct. PMID 30120140, Free PMC Article
    5. Genome sequence of the nematode C. elegans: a platform for investigating biology. C. elegans Sequencing Consortium. Science, 1998 Dec 11. PMID 9851916

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables ATPase activator activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein-folding chaperone binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in [2Fe-2S] cluster assembly IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in [2Fe-2S] cluster assembly IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in protein complex oligomerization IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    is_active_in mitochondrion IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    J domain-containing protein
    NP_001294564.1
    • Confirmed by transcript evidence
    NP_500506.2
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003282.8 Reference assembly

      Range
      4176388..4178364
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_068105.3 → NP_500506.2  J domain-containing protein [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_500506.2

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q21324
      Conserved Domains (1) summary
      PRK05014
      Location:51 → 204
      hscB; co-chaperone HscB; Provisional

    2. NM_001307635.3 → NP_001294564.1  J domain-containing protein [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_001294564.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      U4PF47
      Conserved Domains (1) summary
      PRK00294
      Location:6 → 115
      hscB; co-chaperone HscB; Provisional
    Nucleotide Protein
    Heading Accession and Version

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