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    cdap-2 SH3 domain-containing protein [ Caenorhabditis elegans ]

    Gene ID: 171906, updated on 2-Nov-2024

    Summary

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    Official Symbol
    cdap-2
    Official Full Name
    SH3 domain-containing protein
    Primary source
    WormBase:WBGene00021549
    Locus tag
    CELE_Y44E3A.4
    See related
    AllianceGenome:WB:WBGene00021549
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Predicted to be involved in actin filament organization and cell migration. Human ortholog(s) of this gene implicated in focal segmental glomerulosclerosis; focal segmental glomerulosclerosis 3; and immunodeficiency 61. Orthologous to several human genes including CD2AP (CD2 associated protein). [provided by Alliance of Genome Resources, Nov 2024]
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    Genomic context

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    See cdap-2 in Genome Data Viewer
    Location:
    chromosome: I
    Exon count:
    9
    Sequence:
    Chromosome: I; NC_003279.8 (3318830..3330673, complement)

    Chromosome I - NC_003279.8Genomic Context describing neighboring genes Neighboring gene Carboxylic ester hydrolase Neighboring gene Uncharacterized protein Neighboring gene Thioredoxin Neighboring gene Creatinase_N domain-containing protein;Hydrolase;Uncharacterized protein Neighboring gene FHA domain-containing protein Neighboring gene Hyphal_reg_CWP domain-containing protein

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003279.8

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Genome sequencing of C. elegans balancer strains reveals previously unappreciated complex genomic rearrangements. Maroilley T, et al. Genome Res, 2023 Jan. PMID 36617680, Free PMC Article
    2. ITSN-1 controls vesicle recycling at the neuromuscular junction and functions in parallel with DAB-1. Wang W, et al. Traffic, 2008 May. PMID 18298590, Free PMC Article
    3. SH3 interactome conserves general function over specific form. Xin X, et al. Mol Syst Biol, 2013. PMID 23549480, Free PMC Article
    4. Defect-buffering cellular plasticity increases robustness of metazoan embryogenesis. Xiao L, et al. Cell Syst, 2022 Aug 17. PMID 35882226
    5. Depletion of endogenously biotinylated carboxylases enhances the sensitivity of TurboID-mediated proximity labeling in Caenorhabditis elegans. Artan M, et al. J Biol Chem, 2022 Sep. PMID 35933017, Free PMC Article

    See all (9) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by WormBase

    Process Evidence Code Pubs
    involved_in actin filament organization IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in cell migration IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    SH3 domain-containing protein
    NP_491143.3
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003279.8 Reference assembly

      Range
      3318830..3330673 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_058742.6 → NP_491143.3  SH3 domain-containing protein [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_491143.3

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q6A573
      Conserved Domains (1) summary
      cl17036
      Location:194 → 249
      SH3; Src Homology 3 domain superfamily
    Nucleotide Protein
    Heading Accession and Version

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