ral-1 Small monomeric GTPase [Caenorhabditis elegans] - Gene

Summary

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Official Symbol: ral-1
Official Full Name: Small monomeric GTPase
Primary source: WormBase:WBGene00021811
Locus tag: CELE_Y53G8AR.3
See related: AllianceGenome:WB:WBGene00021811
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Caenorhabditis elegans (strain: Bristol N2)
Lineage: Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary: Predicted to enable GDP binding activity; GTP binding activity; and GTPase activity. Involved in several processes, including determination of adult lifespan; multivesicular body assembly; and positive regulation of vulval development. Predicted to be located in membrane. Predicted to be active in plasma membrane. Is expressed in several structures, including excretory cell; germ line; nervous system; vulva; and vulval precursor cell. Human ortholog(s) of this gene implicated in pancreatic adenocarcinoma. Orthologous to several human genes including RALA (RAS like proto-oncogene A). [provided by Alliance of Genome Resources, Dec 2024]
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Genomic context

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See ral-1 in Genome Data Viewer

Location:: chromosome: III

Exon count:: 7

Sequence:: Chromosome: III; NC_003281.10 (3311310..3317716)

Chromosome III - NC_003281.10 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_003281.10

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

RAL-1 is involved in both multivesicular body formation and their fusion with the plasma membrane.
Title: RAL-1 controls multivesicular body biogenesis and exosome secretion.
lumenal vesicle fusion depends on the small GTPase RAL-1, which localizes to vesicles and acts through the exocyst vesicle-tethering complex.
Title: Polarized exocyst-mediated vesicle fusion directs intracellular lumenogenesis within the C. elegans excretory cell.
Data show that the RAP-1 and RAL-1/exocyst pathway act in parallel during larval stages, and suggest that the exocyst complex acts as a downstream RAL-1 effector in cell migration.
Title: RAP-1 and the RAL-1/exocyst pathway coordinate hypodermal cell organization in Caenorhabditis elegans.

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

Y53G8A_1734.d (e-PCR)
- UniSTS:323080

Homology

Orthologs from OrthoDB

Gene Ontology Provided by WormBase

Function	Evidence Code	Pubs
enables GDP binding	IBA Inferred from Biological aspect of Ancestor more info
enables GTP binding	IBA Inferred from Biological aspect of Ancestor more info
enables GTP binding	IEA Inferred from Electronic Annotation more info
enables GTPase activity	IBA Inferred from Biological aspect of Ancestor more info
enables GTPase activity	IEA Inferred from Electronic Annotation more info
enables GTPase activity	ISS Inferred from Sequence or Structural Similarity more info	PubMed

Process	Evidence Code	Pubs
involved_in Ras protein signal transduction	IBA Inferred from Biological aspect of Ancestor more info
involved_in determination of adult lifespan	IGI Inferred from Genetic Interaction more info	PubMed
involved_in determination of adult lifespan	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in epidermal growth factor receptor signaling pathway	IGI Inferred from Genetic Interaction more info	PubMed
involved_in multivesicular body assembly	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of vulval development	IGI Inferred from Genetic Interaction more info	PubMed
involved_in regulation of exocyst localization	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in signal transduction	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in membrane	IEA Inferred from Electronic Annotation more info
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in plasma membrane	ISS Inferred from Sequence or Structural Similarity more info	PubMed

General protein information

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Preferred Names: Small monomeric GTPase

NP_001254866.1

Confirmed by transcript evidence

NP_001254867.1

Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_003281.10 Reference assembly

Range

3311310..3317716

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_001267937.3 → NP_001254866.1 Small monomeric GTPase [Caenorhabditis elegans]

See identical proteins and their annotated locations for NP_001254866.1

Status: REVIEWED

UniProtKB/TrEMBL

H2L0Q6

Conserved Domains (2) summary

cd04139
Location:59 → 222

RalA_RalB; Ral (Ras-like) family containing highly homologous RalA and RalB

smart00173
Location:59 → 223

RAS; Ras subfamily of RAS small GTPases
NM_001267938.2 → NP_001254867.1 Small monomeric GTPase [Caenorhabditis elegans]

See identical proteins and their annotated locations for NP_001254867.1

Status: REVIEWED

UniProtKB/TrEMBL

Q9N3F8

Conserved Domains (2) summary

cd04139
Location:18 → 181

RalA_RalB; Ral (Ras-like) family containing highly homologous RalA and RalB

smart00173
Location:18 → 182

RAS; Ras subfamily of RAS small GTPases