vps-28 Vacuolar protein sorting-associated protein 28 homolog [Caenorhabditis elegans] - Gene

Summary

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Official Symbol: vps-28
Official Full Name: Vacuolar protein sorting-associated protein 28 homolog
Primary source: WormBase:WBGene00013598
Locus tag: CELE_Y87G2A.10
See related: AllianceGenome:WB:WBGene00013598
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Caenorhabditis elegans (strain: Bristol N2)
Lineage: Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary: Involved in receptor catabolic process. Part of ESCRT I complex. Orthologous to human VPS28 (VPS28 subunit of ESCRT-I). [provided by Alliance of Genome Resources, Nov 2024]
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Genomic context

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See vps-28 in Genome Data Viewer

Location:: chromosome: I

Exon count:: 4

Sequence:: Chromosome: I; NC_003279.8 (13586037..13588831, complement)

Chromosome I - NC_003279.8 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_003279.8

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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Pathways from PubChem

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

Y87G2A.s (e-PCR)
- UniSTS:324519

Homology

Orthologs from OrthoDB

Gene Ontology Provided by WormBase

Function	Evidence Code	Pubs
enables protein-containing complex binding	IBA Inferred from Biological aspect of Ancestor more info

Process	Evidence Code	Pubs
involved_in endosome transport via multivesicular body sorting pathway	IEA Inferred from Electronic Annotation more info
involved_in protein transport	IEA Inferred from Electronic Annotation more info
involved_in protein transport to vacuole involved in ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway	IBA Inferred from Biological aspect of Ancestor more info
involved_in receptor catabolic process	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
part_of ESCRT I complex	IBA Inferred from Biological aspect of Ancestor more info
part_of ESCRT I complex	IEA Inferred from Electronic Annotation more info
part_of ESCRT I complex	IPI Inferred from Physical Interaction more info	PubMed
located_in endosome	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: Vacuolar protein sorting-associated protein 28 homolog

NP_493382.1

Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_003279.8 Reference assembly

Range

13586037..13588831 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_060981.6 → NP_493382.1 Vacuolar protein sorting-associated protein 28 homolog [Caenorhabditis elegans]

See identical proteins and their annotated locations for NP_493382.1

Status: REVIEWED

UniProtKB/Swiss-Prot

Q9NA26

Conserved Domains (1) summary

pfam03997
Location:27 → 205

VPS28; VPS28 protein