trhr-1 Thyrotropin-releasing hormone receptor [Caenorhabditis elegans] - Gene

Summary

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Official Symbol: trhr-1
Official Full Name: Thyrotropin-releasing hormone receptor
Primary source: WormBase:WBGene00016265
Locus tag: CELE_C30F12.6
See related: AllianceGenome:WB:WBGene00016265
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Caenorhabditis elegans (strain: Bristol N2)
Lineage: Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary: Predicted to enable thyrotropin-releasing hormone receptor activity. Predicted to be involved in G protein-coupled receptor signaling pathway. Predicted to be located in membrane. Is expressed in intestine and pharynx. Human ortholog(s) of this gene implicated in congenital nongoitrous hypothyroidism 7 and hypertension. Orthologous to human TRHR (thyrotropin releasing hormone receptor). [provided by Alliance of Genome Resources, Dec 2024]
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Genomic context

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See trhr-1 in Genome Data Viewer

Location:: chromosome: I

Exon count:: 8

Sequence:: Chromosome: I; NC_003279.8 (6989067..6992108)

Chromosome I - NC_003279.8 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_003279.8

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

C30F12.6 (e-PCR)
- UniSTS:313780

STS1-155 (e-PCR)
- UniSTS:241642

Homology

Orthologs from OrthoDB

Gene Ontology Provided by WormBase

Function	Evidence Code	Pubs
enables G protein-coupled receptor activity	IEA Inferred from Electronic Annotation more info
enables thyrotropin-releasing hormone receptor activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in G protein-coupled receptor signaling pathway	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in membrane	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: Thyrotropin-releasing hormone receptor

NP_491990.1

Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

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Reference assembly

Genomic

NC_003279.8 Reference assembly

Range

6989067..6992108

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_059589.8 → NP_491990.1 Thyrotropin-releasing hormone receptor [Caenorhabditis elegans]

See identical proteins and their annotated locations for NP_491990.1

Status: REVIEWED

UniProtKB/TrEMBL

Q95YD7

Conserved Domains (1) summary

cd14995
Location:33 → 349

7tmA_TRH-R; thyrotropin-releasing hormone receptor, member of the class A family of seven-transmembrane G protein-coupled receptors