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    teg-1 GYF domain-containing protein [ Caenorhabditis elegans ]

    Gene ID: 176561, updated on 2-Nov-2024

    Summary

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    Official Symbol
    teg-1
    Official Full Name
    GYF domain-containing protein
    Primary source
    WormBase:WBGene00006563
    Locus tag
    CELE_Y47D3A.27
    See related
    AllianceGenome:WB:WBGene00006563
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Involved in positive regulation of miRNA processing and positive regulation of stem cell differentiation. Located in cytoplasm and nucleoplasm. Is expressed in seam cell; uterus; and vulva. Orthologous to human CD2BP2 (CD2 cytoplasmic tail binding protein 2). [provided by Alliance of Genome Resources, Nov 2024]
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    Genomic context

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    See teg-1 in Genome Data Viewer
    Location:
    chromosome: III
    Exon count:
    5
    Sequence:
    Chromosome: III; NC_003281.10 (11312229..11317055, complement)

    Chromosome III - NC_003281.10Genomic Context describing neighboring genes Neighboring gene Structural maintenance of chromosomes protein 3 Neighboring gene Ras-related protein Rab-35 Neighboring gene Protein MCM10 homolog Neighboring gene GTP-binding protein 128up;OBG-type G domain-containing protein Neighboring gene CUB domain-containing protein

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003281.10

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. TEG-1 CD2BP2 controls miRNA levels by regulating miRISC stability in C. elegans and human cells. Wang C, et al. Nucleic Acids Res, 2017 Feb 17. PMID 28180320, Free PMC Article
    2. TEG-1 CD2BP2 regulates stem cell proliferation and sex determination in the C. elegans germ line and physically interacts with the UAF-1 U2AF65 splicing factor. Wang C, et al. Dev Dyn, 2012 Mar. PMID 22275078, Free PMC Article
    3. Conservation of caspase substrates across metazoans suggests hierarchical importance of signaling pathways over specific targets and cleavage site motifs in apoptosis. Crawford ED, et al. Cell Death Differ, 2012 Dec. PMID 22918439, Free PMC Article
    4. Novel LOTUS-domain proteins are organizational hubs that recruit C. elegans Vasa to germ granules. Cipriani PG, et al. Elife, 2021 Jul 5. PMID 34223818, Free PMC Article
    5. A map of the interactome network of the metazoan C. elegans. Li S, et al. Science, 2004 Jan 23. PMID 14704431, Free PMC Article

    See all (8) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. TEG-1 regulates the stability of two miRISC effectors, VIG-1 and ALG-1, which in turn affects the abundance of miRNAs in various families.
      Title: TEG-1 CD2BP2 controls miRNA levels by regulating miRISC stability in C. elegans and human cells.
    2. TEG-1 functions as a splicing factor and acts to regulate the proliferation versus meiosis decision.
      Title: TEG-1 CD2BP2 regulates stem cell proliferation and sex determination in the C. elegans germ line and physically interacts with the UAF-1 U2AF65 splicing factor.
    Submit: New GeneRIF Correction

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in positive regulation of miRNA processing IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in positive regulation of stem cell differentiation IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    Component Evidence Code Pubs
    part_of U5 snRNP IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of U5 snRNP IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in nucleoplasm IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    GYF domain-containing protein
    NP_499455.2
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003281.10 Reference assembly

      Range
      11312229..11317055 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_067054.8 → NP_499455.2  GYF domain-containing protein [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_499455.2

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q9NAH3
    Nucleotide Protein
    Heading Accession and Version

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