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    cpn-3 Calponin-homology (CH) domain-containing protein [ Caenorhabditis elegans ]

    Gene ID: 171986, updated on 9-Dec-2024

    Summary

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    Official Symbol
    cpn-3
    Official Full Name
    Calponin-homology (CH) domain-containing protein
    Primary source
    WormBase:WBGene00000779
    Locus tag
    CELE_F28H1.2
    See related
    AllianceGenome:WB:WBGene00000779
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Predicted to enable actin filament binding activity. Predicted to be involved in actin filament organization. Located in myofibril. Is expressed in anal region; body wall musculature; egg-laying apparatus; enteric muscle; and head neurons. [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See cpn-3 in Genome Data Viewer
    Location:
    chromosome: I
    Exon count:
    4
    Sequence:
    Chromosome: I; NC_003279.8 (3987940..3988699)

    Chromosome I - NC_003279.8Genomic Context describing neighboring genes Neighboring gene Uncharacterized protein Neighboring gene Alanine--tRNA ligase, cytoplasmic Neighboring gene Uncharacterized protein Neighboring gene CRAL-TRIO domain-containing protein;DH domain-containing protein;Rho guanine nucleotide exchange factor 26;Triple functional domain protein Neighboring gene Uncharacterized protein

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003279.8

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. The embryonic muscle transcriptome of Caenorhabditis elegans. Fox RM, et al. Genome Biol, 2007. PMID 17848203, Free PMC Article
    2. Cell size and fat content of dietary-restricted Caenorhabditis elegans are regulated by ATX-2, an mTOR repressor. Bar DZ, et al. Proc Natl Acad Sci U S A, 2016 Aug 9. PMID 27457958, Free PMC Article
    3. Distinct patterns of gene and protein expression elicited by organophosphorus pesticides in Caenorhabditis elegans. Lewis JA, et al. BMC Genomics, 2009 Apr 29. PMID 19402892, Free PMC Article
    4. Determining the sub-cellular localization of proteins within Caenorhabditis elegans body wall muscle. Meissner B, et al. PLoS One, 2011. PMID 21611156, Free PMC Article
    5. CCAR-1 works together with the U2AF large subunit UAF-1 to regulate alternative splicing. Lugano DI, et al. RNA Biol, 2024 Jan. PMID 38126797, Free PMC Article

    See all (13) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables actin filament binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in actin filament organization IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in actin cytoskeleton IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in myofibril HDA PubMed 

    General protein information

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    Preferred Names
    Calponin-homology (CH) domain-containing protein
    NP_491282.1
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003279.8 Reference assembly

      Range
      3987940..3988699
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_058881.7 → NP_491282.1  Calponin-homology (CH) domain-containing protein [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_491282.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      O01542
      Conserved Domains (1) summary
      cd00014
      Location:30 → 133
      CH; Calponin homology domain; actin-binding domain which may be present as a single copy or in tandem repeats (which increases binding affinity). The CH domain is found in cytoskeletal and signal transduction proteins, including actin-binding proteins like ...
    Nucleotide Protein
    Heading Accession and Version

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