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    fum-1 putative fumarate hydratase, mitochondrial [ Caenorhabditis elegans ]

    Gene ID: 176059, updated on 2-Nov-2024

    Summary

    Official Symbol
    fum-1
    Official Full Name
    putative fumarate hydratase, mitochondrial
    Primary source
    WormBase:WBGene00001503
    Locus tag
    CELE_H14A12.2
    See related
    AllianceGenome:WB:WBGene00001503
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Predicted to enable fumarate hydratase activity. Predicted to be involved in fumarate metabolic process; malate metabolic process; and tricarboxylic acid cycle. Located in mitochondrion. Human ortholog(s) of this gene implicated in fumarase deficiency and lung non-small cell carcinoma. Orthologous to human FH (fumarate hydratase). [provided by Alliance of Genome Resources, Nov 2024]
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    Genomic context

    See fum-1 in Genome Data Viewer
    Location:
    chromosome: III
    Exon count:
    4
    Sequence:
    Chromosome: III; NC_003281.10 (7465605..7467640)

    Chromosome III - NC_003281.10Genomic Context describing neighboring genes Neighboring gene FIP (Fungus-Induced Protein) Related Neighboring gene Protein rogdi homolog Neighboring gene ncRNA Neighboring gene tRNA-synt_2 domain-containing protein Neighboring gene Transmembrane matrix receptor MUP-4 Neighboring gene ncRNA

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables catalytic activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables fumarate hydratase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables fumarate hydratase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables lyase activity IEA
    Inferred from Electronic Annotation
    more info
     
    Process Evidence Code Pubs
    involved_in fumarate metabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in fumarate metabolic process IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in malate metabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in tricarboxylic acid cycle IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in tricarboxylic acid cycle IEA
    Inferred from Electronic Annotation
    more info
     
    Component Evidence Code Pubs
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
     
    located_in mitochondrial matrix IEA
    Inferred from Electronic Annotation
    more info
     
    located_in mitochondrion HDA PubMed 
    is_active_in mitochondrion IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in mitochondrion IEA
    Inferred from Electronic Annotation
    more info
     

    General protein information

    Preferred Names
    putative fumarate hydratase, mitochondrial
    NP_498642.1
    • Partially confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003281.10 Reference assembly

      Range
      7465605..7467640
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_066241.8NP_498642.1  putative fumarate hydratase, mitochondrial [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_498642.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      O17214
      Conserved Domains (2) summary
      cd01362
      Location:42497
      Fumarase_classII; Class II fumarases
      PRK00485
      Location:38501
      fumC; fumarate hydratase; Reviewed