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    cytb-5.1 Cytochrome b5 heme-binding domain-containing protein [ Caenorhabditis elegans ]

    Gene ID: 181510, updated on 2-Nov-2024

    Summary

    Official Symbol
    cytb-5.1
    Official Full Name
    Cytochrome b5 heme-binding domain-containing protein
    Primary source
    WormBase:WBGene00007848
    Locus tag
    CELE_C31E10.7
    See related
    AllianceGenome:WB:WBGene00007848
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Predicted to enable heme binding activity. Located in perinuclear region of cytoplasm. Is expressed in intestine. Used to study hematopoietic system disease. Human ortholog(s) of this gene implicated in methemoglobinemia and methemoglobinemia and ambiguous genitalia. Orthologous to human CYB5A (cytochrome b5 type A) and CYB5B (cytochrome b5 type B). [provided by Alliance of Genome Resources, Nov 2024]
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    Genomic context

    See cytb-5.1 in Genome Data Viewer
    Location:
    chromosome: X
    Exon count:
    4
    Sequence:
    Chromosome: X; NC_003284.9 (14001924..14003080)

    Chromosome X - NC_003284.9Genomic Context describing neighboring genes Neighboring gene CCDC93 N-terminal domain-containing protein Neighboring gene CCDC93 N-terminal domain-containing protein Neighboring gene TBC1 domain family member 2B Neighboring gene tRNA-Gly Neighboring gene ncRNA Neighboring gene Nematode Specific Peptide family, group A

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables heme binding IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables heme binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
     
    Component Evidence Code Pubs
    is_active_in intracellular membrane-bounded organelle IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    is_active_in membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
     
    located_in perinuclear region of cytoplasm IDA
    Inferred from Direct Assay
    more info
    PubMed 

    General protein information

    Preferred Names
    Cytochrome b5 heme-binding domain-containing protein
    NP_510335.2
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003284.9 Reference assembly

      Range
      14001924..14003080
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_077934.9NP_510335.2  Cytochrome b5 heme-binding domain-containing protein [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_510335.2

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q93315
      Conserved Domains (1) summary
      pfam00173
      Location:880
      Cyt-b5; Cytochrome b5-like Heme/Steroid binding domain