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    cyc-2.2 putative cytochrome c 2.2 [ Caenorhabditis elegans ]

    Gene ID: 179728, updated on 9-Dec-2024

    Summary

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    Official Symbol
    cyc-2.2
    Official Full Name
    putative cytochrome c 2.2
    Primary source
    WormBase:WBGene00013854
    Locus tag
    CELE_ZC116.2
    See related
    AllianceGenome:WB:WBGene00013854
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Predicted to enable electron transfer activity. Predicted to be involved in mitochondrial electron transport, cytochrome c to oxygen and mitochondrial electron transport, ubiquinol to cytochrome c. Predicted to be located in mitochondrion. Predicted to be part of respiratory chain complex. Predicted to be active in mitochondrial intermembrane space. Human ortholog(s) of this gene implicated in cholangiocarcinoma; lung non-small cell carcinoma; pancreatic cancer; and thrombocytopenia. Orthologous to human CYCS (cytochrome c, somatic). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See cyc-2.2 in Genome Data Viewer
    Location:
    chromosome: V
    Exon count:
    3
    Sequence:
    Chromosome: V; NC_003283.11 (12611682..12612218, complement)

    Chromosome V - NC_003283.11Genomic Context describing neighboring genes Neighboring gene putative ergosterol biosynthetic protein 28 homolog Neighboring gene Conserved secreted protein Neighboring gene Prion-like-(Q/N-rich)-domain-bearing protein Neighboring gene Cubilin homolog Neighboring gene FIP (Fungus-Induced Protein) Related Neighboring gene C6 domain-containing protein

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003283.11

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Recombinant expression, biophysical characterization, and cardiolipin-induced changes of two Caenorhabditis elegans cytochrome c proteins. Vincelli AJ, et al. Biochemistry, 2013 Jan 29. PMID 23282202, Free PMC Article
    2. Caenorhabditis elegans par2.1/mtssb-1 is essential for mitochondrial DNA replication and its defect causes comprehensive transcriptional alterations including a hypoxia response. Sugimoto T, et al. Exp Cell Res, 2008 Jan 1. PMID 17900564
    3. EPIC: software toolkit for elution profile-based inference of protein complexes. Hu LZ, et al. Nat Methods, 2019 Aug. PMID 31308550, Free PMC Article
    4. OrthoList: a compendium of C. elegans genes with human orthologs. Shaye DD, et al. PLoS One, 2011. PMID 21647448, Free PMC Article
    5. OrthoList 2: A New Comparative Genomic Analysis of Human and Caenorhabditis elegans Genes. Kim W, et al. Genetics, 2018 Oct. PMID 30120140, Free PMC Article

    See all (6) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Distinct peroxidase activities of CYC-2.1 and CYC-2.2 in the presence of cardiolipin arise from differences in the local heme environments.
      Title: Recombinant expression, biophysical characterization, and cardiolipin-induced changes of two Caenorhabditis elegans cytochrome c proteins.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables electron transfer activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables electron transfer activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables heme binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in mitochondrial electron transport, cytochrome c to oxygen IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in mitochondrial electron transport, ubiquinol to cytochrome c IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in mitochondrial intermembrane space IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in mitochondrial intermembrane space IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in mitochondrion IEA
    Inferred from Electronic Annotation
    more info
    		  
    part_of respiratory chain complex IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    putative cytochrome c 2.2
    NP_506156.1
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003283.11 Reference assembly

      Range
      12611682..12612218 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_073755.5 → NP_506156.1  putative cytochrome c 2.2 [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_506156.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q23240
      Conserved Domains (1) summary
      COG3474
      Location:16 → 120
      Cyc7; Cytochrome c2 [Energy production and conversion]
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q23240.1

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