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    bug-1 EGF-like domain-containing protein [ Caenorhabditis elegans ]

    Gene ID: 179859, updated on 9-Dec-2024

    Summary

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    Official Symbol
    bug-1
    Official Full Name
    EGF-like domain-containing protein
    Primary source
    WormBase:WBGene00011326
    Locus tag
    CELE_T01D3.1
    See related
    AllianceGenome:WB:WBGene00011326
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Predicted to enable calcium ion binding activity. Predicted to be involved in motor neuron axon guidance. Predicted to be located in membrane. Is expressed in nervous system. [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See bug-1 in Genome Data Viewer
    Location:
    chromosome: V
    Exon count:
    23
    Sequence:
    Chromosome: V; NC_003283.11 (13689892..13703330)

    Chromosome V - NC_003283.11Genomic Context describing neighboring genes Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene TIL domain-containing protein;Thyroglobulin type-1 domain-containing protein Neighboring gene Helix-loop-helix 34

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003283.11

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Dose-dependent functions of SWI/SNF BAF in permitting and inhibiting cell proliferation in vivo. van der Vaart A, et al. Sci Adv, 2020 May. PMID 32494730, Free PMC Article
    2. Meta-Analysis of Caenorhabditis elegans Transcriptomics Implicates Hedgehog-Like Signaling in Host-Microbe Interactions. Zárate-Potes A, et al. Front Microbiol, 2022. PMID 35620104, Free PMC Article
    3. A global analysis of genetic interactions in Caenorhabditis elegans. Byrne AB, et al. J Biol, 2007. PMID 17897480, Free PMC Article
    4. OrthoList 2: A New Comparative Genomic Analysis of Human and Caenorhabditis elegans Genes. Kim W, et al. Genetics, 2018 Oct. PMID 30120140, Free PMC Article
    5. Genome sequence of the nematode C. elegans: a platform for investigating biology. C. elegans Sequencing Consortium. Science, 1998 Dec 11. PMID 9851916

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables calcium ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in cellular component organization IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in motor neuron axon guidance IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    EGF-like domain-containing protein
    NP_001256538.1
    • Confirmed by transcript evidence
    NP_001256539.1
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003283.11 Reference assembly

      Range
      13689892..13703330
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001269610.2 → NP_001256539.1  EGF-like domain-containing protein [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_001256539.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      G5EEP6

    2. NM_001269609.3 → NP_001256538.1  EGF-like domain-containing protein [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_001256538.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      H9G306
      Conserved Domains (5) summary
      cd11304
      Location:2692 → 2776
      Cadherin_repeat; Cadherin tandem repeat domain
      pfam07974
      Location:1175 → 1198
      EGF_2; EGF-like domain
      pfam13229
      Location:392 → 544
      Beta_helix; Right handed beta helix region
      pfam15950
      Location:2952 → 3130
      DUF4758; Domain of unknown function (DUF4758)
      cl19567
      Location:1188 → 1230
      DSL; Delta serrate ligand
    Nucleotide Protein
    Heading Accession and Version

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