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    lsm-1 U6 snRNA-associated Sm-like protein LSm1 [ Caenorhabditis elegans ]

    Gene ID: 174700, updated on 9-Dec-2024

    Summary

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    Official Symbol
    lsm-1
    Official Full Name
    U6 snRNA-associated Sm-like protein LSm1
    Primary source
    WormBase:WBGene00003076
    Locus tag
    CELE_F40F8.9
    See related
    AllianceGenome:WB:WBGene00003076
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Predicted to enable mRNA binding activity. Predicted to be involved in deadenylation-dependent decapping of nuclear-transcribed mRNA. Located in P-body and cytoplasmic stress granule. Is expressed in germ line and somatic cell. Orthologous to human LSM1 (LSM1 homolog, mRNA degradation associated). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See lsm-1 in Genome Data Viewer
    Location:
    chromosome: II
    Exon count:
    2
    Sequence:
    Chromosome: II; NC_003280.10 (11126950..11127528)

    Chromosome II - NC_003280.10Genomic Context describing neighboring genes Neighboring gene Lon proteolytic domain-containing protein Neighboring gene Small ribosomal subunit protein uS4 Neighboring gene UMP-CMP kinase;UMP-CMP kinase 2 Neighboring gene Transmembrane protein 42 Neighboring gene Uncharacterized protein

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003280.10

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Cytoplasmic LSM-1 protein regulates stress responses through the insulin/IGF-1 signaling pathway in Caenorhabditis elegans. Cornes E, et al. RNA, 2015 Sep. PMID 26150554, Free PMC Article
    2. LSM2-8 and XRN-2 contribute to the silencing of H3K27me3-marked genes through targeted RNA decay. Mattout A, et al. Nat Cell Biol, 2020 May. PMID 32251399, Free PMC Article
    3. Processing bodies and germ granules are distinct RNA granules that interact in C. elegans embryos. Gallo CM, et al. Dev Biol, 2008 Nov 1. PMID 18692039
    4. Large-scale RNAi screens identify novel genes that interact with the C. elegans retinoblastoma pathway as well as splicing-related components with synMuv B activity. Ceron J, et al. BMC Dev Biol, 2007 Apr 6. PMID 17417969, Free PMC Article
    5. Novel LOTUS-domain proteins are organizational hubs that recruit C. elegans Vasa to germ granules. Cipriani PG, et al. Elife, 2021 Jul 5. PMID 34223818, Free PMC Article

    See all (9) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Results show that LSM-1 and LSM-3 are not essential for Caenorhabditis elegans viability but contribute to the regulation of development, reproduction, and motility.
      Title: Cytoplasmic LSM-1 protein regulates stress responses through the insulin/IGF-1 signaling pathway in Caenorhabditis elegans.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables RNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables RNA cap binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables mRNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in RNA splicing IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in deadenylation-dependent decapping of nuclear-transcribed mRNA IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in mRNA processing IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    part_of Lsm1-7-Pat1 complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in P-body IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in P-body IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in P-body IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytoplasmic stress granule IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    part_of spliceosomal complex IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    U6 snRNA-associated Sm-like protein LSm1
    NP_496385.1
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003280.10 Reference assembly

      Range
      11126950..11127528
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_063984.6 → NP_496385.1  U6 snRNA-associated Sm-like protein LSm1 [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_496385.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q20229
      Conserved Domains (1) summary
      cd01728
      Location:8 → 81
      LSm1; Like-Sm protein 1
    Nucleotide Protein
    Heading Accession and Version

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