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    crn-3 Exosome complex component 10 homolog [ Caenorhabditis elegans ]

    Gene ID: 3565889, updated on 14-Nov-2024

    Summary

    Official Symbol
    crn-3
    Official Full Name
    Exosome complex component 10 homolog
    Primary source
    WormBase:WBGene00000796
    Locus tag
    CELE_C14A4.4
    See related
    AllianceGenome:WB:WBGene00000796
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Predicted to enable 3'-5'-RNA exonuclease activity and single-stranded RNA binding activity. Involved in apoptotic DNA fragmentation and apoptotic cell clearance. Predicted to be located in nucleoplasm. Predicted to be part of nuclear exosome (RNase complex). Predicted to be active in nucleolus. Is expressed widely. Orthologous to human EXOSC10 (exosome component 10). [provided by Alliance of Genome Resources, Nov 2024]
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    Genomic context

    See crn-3 in Genome Data Viewer
    Location:
    chromosome: II
    Exon count:
    5
    Sequence:
    Chromosome: II; NC_003280.10 (10588042..10592652)

    Chromosome II - NC_003280.10Genomic Context describing neighboring genes Neighboring gene Mitochondrial Ribosomal Protein, Small Neighboring gene Alpha-1,2-mannosyltransferase algn-9 Neighboring gene Exosome complex component RRP46 homolog Neighboring gene MARVEL domain-containing protein Neighboring gene MARVEL domain-containing protein;Transmembrane protein

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables 3'-5' exonuclease activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables 3'-5'-RNA exonuclease activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables 3'-5'-RNA exonuclease activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables exonuclease activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables nucleic acid binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables nucleotide binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables single-stranded RNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    Process Evidence Code Pubs
    involved_in RNA processing IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in RNA processing TAS
    Traceable Author Statement
    more info
    PubMed 
    involved_in TRAMP-dependent tRNA surveillance pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in apoptotic DNA fragmentation IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    involved_in apoptotic DNA fragmentation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in apoptotic cell clearance IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in apoptotic process IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in exonucleolytic trimming to generate mature 3'-end of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in exonucleolytic trimming to generate mature 3'-end of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in histone mRNA catabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in metabolic process IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in nuclear polyadenylation-dependent CUT catabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in nuclear polyadenylation-dependent antisense transcript catabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in nuclear polyadenylation-dependent rRNA catabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in nuclear polyadenylation-dependent snRNA catabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in nuclear polyadenylation-dependent snoRNA catabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in nucleic acid metabolic process IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in nucleobase-containing compound metabolic process IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in poly(A)-dependent snoRNA 3'-end processing IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in rRNA processing IEA
    Inferred from Electronic Annotation
    more info
     
    Component Evidence Code Pubs
    part_of exosome (RNase complex) IEA
    Inferred from Electronic Annotation
    more info
     
    part_of exosome (RNase complex) TAS
    Traceable Author Statement
    more info
    PubMed 
    part_of nuclear exosome (RNase complex) IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    part_of nuclear exosome (RNase complex) IEA
    Inferred from Electronic Annotation
    more info
     
    is_active_in nucleolus IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in nucleolus IEA
    Inferred from Electronic Annotation
    more info
     
    located_in nucleoplasm IEA
    Inferred from Electronic Annotation
    more info
     
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
     

    General protein information

    Preferred Names
    Exosome complex component 10 homolog
    NP_001379075.1
    • Confirmed by transcript evidence
    NP_001417852.1
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003280.10 Reference assembly

      Range
      10588042..10592652
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001393179.1NP_001379075.1  Exosome complex component 10 homolog [Caenorhabditis elegans]

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      G5EBX6, Q8I129
      Conserved Domains (3) summary
      cd06147
      Location:274466
      Rrp6p_like_exo; DEDDy 3'-5' exonuclease domain of yeast Rrp6p, human polymyositis/scleroderma autoantigen 100kDa, and similar proteins
      smart00341
      Location:489569
      HRDC; Helicase and RNase D C-terminal
      pfam08066
      Location:44134
      PMC2NT; PMC2NT (NUC016) domain
    2. NM_001430931.1NP_001417852.1  Exosome complex component 10 homolog [Caenorhabditis elegans]

      Status: REVIEWED