glr-2 Glutamate receptor 2 [Caenorhabditis elegans] - Gene

Summary

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Official Symbol: glr-2
Official Full Name: Glutamate receptor 2
Primary source: WormBase:WBGene00001613
Locus tag: CELE_B0280.12
See related: AllianceGenome:WB:WBGene00001613
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Caenorhabditis elegans (strain: Bristol N2)
Lineage: Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary: Predicted to enable glutamate receptor activity and transmitter-gated monoatomic ion channel activity involved in regulation of postsynaptic membrane potential. Predicted to be involved in glutamatergic synaptic transmission and modulation of chemical synaptic transmission. Predicted to be located in postsynaptic membrane. Predicted to be active in postsynaptic density membrane. Is expressed in several structures, including M1 neuron; RMD; interneuron; linker cell; and nerve ring. Human ortholog(s) of this gene implicated in autosomal dominant intellectual developmental disorder; autosomal recessive intellectual developmental disorder 76; epilepsy; schizophrenia; and syndromic X-linked intellectual disability 94. Orthologous to several human genes including GRIA1 (glutamate ionotropic receptor AMPA type subunit 1); GRIA2 (glutamate ionotropic receptor AMPA type subunit 2); and GRIA3 (glutamate ionotropic receptor AMPA type subunit 3). [provided by Alliance of Genome Resources, Nov 2024]
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Genomic context

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See glr-2 in Genome Data Viewer

Location:: chromosome: III

Exon count:: 20

Sequence:: Chromosome: III; NC_003281.10 (7138640..7144959, complement)

Chromosome III - NC_003281.10 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_003281.10

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

previously-stimulated animals later habituate to subsequent mechanostimulation more rapidly compared to animals initially reared without mechanical stimulation; MAGI-1L, GLR-1, and GLR-2 are required for this change in habituation kinetics.
Title: MAGI-1 modulates AMPA receptor synaptic localization and behavioral plasticity in response to prior experience.
unfolded protein response signaling is a critical step in neural function that is needed for GLR-1, GLR-2, and GLR-5 assembly and secretion
Title: The unfolded protein response regulates glutamate receptor export from the endoplasmic reticulum.
An arginine residue was introduced into the pore loop of glutamate receptor subunit, GLR-2. Synaptically activated GLR-2R-containing iGluR channels appear to trigger inappropriate, neurotoxic Ca2+ release from intracellular stores.
Title: Neuronal toxicity in Caenorhabditis elegans from an editing site mutant in glutamate receptor channels.
results show that while the osmotic avoidance response requires both NMDA and non-NMDA receptors, the response to mechanical stimuli only requires non-NMDA receptors
Title: Decoding of polymodal sensory stimuli by postsynaptic glutamate receptors in C. elegans.
Cytosolic tail sequences and subunit interactions of GLR-1 and GLR-2 are critical for synaptic localization of glutamate receptors
Title: Cytosolic tail sequences and subunit interactions are critical for synaptic localization of glutamate receptors.

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

B0280.12 (e-PCR)
- UniSTS:313378

K04G7.2 (e-PCR)
- UniSTS:318316

Homology

Orthologs from OrthoDB

Gene Ontology Provided by WormBase

Function	Evidence Code	Pubs
enables glutamate receptor activity	IBA Inferred from Biological aspect of Ancestor more info
enables ligand-gated monoatomic ion channel activity	IEA Inferred from Electronic Annotation more info
enables monoatomic ion channel activity	IEA Inferred from Electronic Annotation more info
enables signaling receptor activity	IEA Inferred from Electronic Annotation more info
enables transmitter-gated monoatomic ion channel activity involved in regulation of postsynaptic membrane potential	IBA Inferred from Biological aspect of Ancestor more info

Process	Evidence Code	Pubs
involved_in ionotropic glutamate receptor signaling pathway	IEA Inferred from Electronic Annotation more info
involved_in modulation of chemical synaptic transmission	IBA Inferred from Biological aspect of Ancestor more info
involved_in monoatomic ion transmembrane transport	IEA Inferred from Electronic Annotation more info
involved_in monoatomic ion transport	IEA Inferred from Electronic Annotation more info
involved_in regulation of postsynaptic membrane potential	IEA Inferred from Electronic Annotation more info
involved_in synaptic transmission, glutamatergic	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
located_in membrane	IEA Inferred from Electronic Annotation more info
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in plasma membrane	IEA Inferred from Electronic Annotation more info
is_active_in postsynaptic density membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in postsynaptic membrane	IEA Inferred from Electronic Annotation more info
located_in synapse	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: Glutamate receptor 2

NP_001021113.1

Confirmed by transcript evidence

NP_001021114.1

Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_003281.10 Reference assembly

Range

7138640..7144959 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_001025943.3 → NP_001021114.1 Glutamate receptor 2 [Caenorhabditis elegans]

See identical proteins and their annotated locations for NP_001021114.1

Status: REVIEWED

UniProtKB/Swiss-Prot

Q10914, Q86GT2, Q9BK24

Conserved Domains (3) summary

pfam00060
Location:621 → 910

Lig_chan; Ligand-gated ion channel

cl10011
Location:7 → 453

Periplasmic_Binding_Protein_Type_1; Type 1 periplasmic binding fold superfamily

cl21456
Location:491 → 875

Periplasmic_Binding_Protein_Type_2; Type 2 periplasmic binding fold superfamily
NM_001025942.4 → NP_001021113.1 Glutamate receptor 2 [Caenorhabditis elegans]

See identical proteins and their annotated locations for NP_001021113.1

Status: REVIEWED

UniProtKB/Swiss-Prot

Q10914

Conserved Domains (3) summary

pfam00060
Location:552 → 841

Lig_chan; Ligand-gated ion channel

cl10011
Location:7 → 384

Periplasmic_Binding_Protein_Type_1; Type 1 periplasmic binding fold superfamily

cl21456
Location:422 → 806

Periplasmic_Binding_Protein_Type_2; Type 2 periplasmic binding fold superfamily