cdc-25.1 M-phase inducer phosphatase cdc-25.1 [Caenorhabditis elegans] - Gene

Summary

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Official Symbol: cdc-25.1
Official Full Name: M-phase inducer phosphatase cdc-25.1
Primary source: WormBase:WBGene00000386
Locus tag: CELE_K06A5.7
See related: AllianceGenome:WB:WBGene00000386
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Caenorhabditis elegans (strain: Bristol N2)
Lineage: Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary: Predicted to enable protein tyrosine phosphatase activity. Involved in meiotic spindle organization and positive regulation of mitotic cell cycle. Located in nucleus. Is expressed in several structures, including Z2; Z3; germ line; oocyte; and sperm. [provided by Alliance of Genome Resources, Nov 2024]
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Genomic context

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See cdc-25.1 in Genome Data Viewer

Location:: chromosome: I

Exon count:: 7

Sequence:: Chromosome: I; NC_003279.8 (6469386..6471922, complement)

Chromosome I - NC_003279.8 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_003279.8

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

results indicate that CDC-25.1 is required for maintaining proper rate of germline mitotic cell cycle; propose that CDC-25.1 regulates the rate of germline mitotic cell cycle by counteracting WEE-1.3 and by positively controlling CDK-1
Title: CDC-25.1 controls the rate of germline mitotic cell cycle by counteracting WEE-1.3 and by positively regulating CDK-1 in Caenorhabditis elegans.
Findings indicate that the function of cdc-25.1 is unique in the germ line but likely redundant with other members in the soma.
Title: A mutation of cdc-25.1 causes defects in germ cells but not in somatic tissues in C. elegans.
Levels of maternal transcripts are reduced, including cdc-25.1, while zygotic transcripts appear unperturbed, suggesting a germ-line-specific role for this splicing factor in regulating the splicing, and the steady-state levels of maternal transcripts.
Title: Suppressors of the cdc-25.1(gf)-associated intestinal hyperplasia reveal important maternal roles for prp-8 and a subset of splicing factors in C. elegans.
cdc-25.1 stability is regulated by distinct domains to restrict cell division during embryogenesis in C. elegans.
Title: CDC-25.1 stability is regulated by distinct domains to restrict cell division during embryogenesis in C. elegans.
We suggest that control of Plk1 and Cdc25 may be relevant to regulation of cell cycle length in other developmental contexts.
Title: PAR proteins direct asymmetry of the cell cycle regulators Polo-like kinase and Cdc25.

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

K06A5.7 (e-PCR)
- UniSTS:317505

Homology

Orthologs from OrthoDB

Gene Ontology Provided by WormBase

Function	Evidence Code	Pubs
enables phosphoprotein phosphatase activity	IEA Inferred from Electronic Annotation more info
enables phosphoprotein phosphatase activity	ISS Inferred from Sequence or Structural Similarity more info	PubMed
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein tyrosine phosphatase activity	IBA Inferred from Biological aspect of Ancestor more info
enables protein tyrosine phosphatase activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in G2/M transition of mitotic cell cycle	IBA Inferred from Biological aspect of Ancestor more info
involved_in cell cycle	IEA Inferred from Electronic Annotation more info
involved_in cell division	IEA Inferred from Electronic Annotation more info
involved_in meiotic cell cycle	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in meiotic spindle organization	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of G2/M transition of mitotic cell cycle	IBA Inferred from Biological aspect of Ancestor more info
involved_in positive regulation of G2/MI transition of meiotic cell cycle	IBA Inferred from Biological aspect of Ancestor more info
involved_in positive regulation of cell cycle G2/M phase transition	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of mitotic cell cycle	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in protein dephosphorylation	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleus	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: M-phase inducer phosphatase cdc-25.1

NP_491862.1

Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_003279.8 Reference assembly

Range

6469386..6471922 complement

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_059461.6 → NP_491862.1 M-phase inducer phosphatase cdc-25.1 [Caenorhabditis elegans]

See identical proteins and their annotated locations for NP_491862.1

Status: REVIEWED

UniProtKB/Swiss-Prot

O44552

Conserved Domains (1) summary

cd01530
Location:286 → 406

Cdc25; Cdc25 phosphatases are members of the Rhodanese Homology Domain superfamily. They activate the cell division kinases throughout the cell cycle progression. Cdc25 phosphatases dephosphorylate phosphotyrosine and phosphothreonine residues, in order to ...