Y48A6B.3 Putative H/ACA ribonucleoprotein complex subunit 2-like protein [Caenorhabditis elegans] - Gene

Summary

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Official Symbol: Y48A6B.3
Official Full Name: Putative H/ACA ribonucleoprotein complex subunit 2-like protein
Primary source: WormBase:WBGene00012964
Locus tag: CELE_Y48A6B.3
See related: AllianceGenome:WB:WBGene00012964
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Caenorhabditis elegans (strain: Bristol N2)
Lineage: Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary: Predicted to enable box H/ACA snoRNA binding activity. Predicted to be involved in rRNA pseudouridine synthesis and snRNA pseudouridine synthesis. Predicted to be located in nucleolus. Predicted to be part of box H/ACA snoRNP complex. Human ortholog(s) of this gene implicated in autosomal recessive dyskeratosis congenita 2. Orthologous to human NHP2 (NHP2 ribonucleoprotein). [provided by Alliance of Genome Resources, Nov 2024]
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Genomic context

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See Y48A6B.3 in Genome Data Viewer

Location:: chromosome: III

Exon count:: 3

Sequence:: Chromosome: III; NC_003281.10 (11008222..11008929)

Chromosome III - NC_003281.10 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_003281.10

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

Y48A6B.4 (e-PCR)
- UniSTS:316210

Y48A6B.3 (e-PCR)
- UniSTS:320647

Homology

Orthologs from OrthoDB

Gene Ontology Provided by WormBase

Function	Evidence Code	Pubs
enables RNA binding	IEA Inferred from Electronic Annotation more info
enables box H/ACA snoRNA binding	IBA Inferred from Biological aspect of Ancestor more info

Process	Evidence Code	Pubs
involved_in rRNA processing	IEA Inferred from Electronic Annotation more info
involved_in rRNA pseudouridine synthesis	IBA Inferred from Biological aspect of Ancestor more info
involved_in rRNA pseudouridine synthesis	ISS Inferred from Sequence or Structural Similarity more info
involved_in ribosome biogenesis	IEA Inferred from Electronic Annotation more info
involved_in snRNA pseudouridine synthesis	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
part_of box H/ACA snoRNP complex	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleolus	IEA Inferred from Electronic Annotation more info
located_in nucleus	IEA Inferred from Electronic Annotation more info
part_of ribonucleoprotein complex	IEA Inferred from Electronic Annotation more info
part_of sno(s)RNA-containing ribonucleoprotein complex	ISS Inferred from Sequence or Structural Similarity more info

General protein information

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Preferred Names: Putative H/ACA ribonucleoprotein complex subunit 2-like protein

NP_499415.1

Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_003281.10 Reference assembly

Range

11008222..11008929

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_067014.8 → NP_499415.1 Putative H/ACA ribonucleoprotein complex subunit 2-like protein [Caenorhabditis elegans]

See identical proteins and their annotated locations for NP_499415.1

Status: REVIEWED

UniProtKB/Swiss-Prot

Q9XXD4

Conserved Domains (1) summary

pfam01248
Location:53 → 148

Ribosomal_L7Ae; Ribosomal protein L7Ae/L30e/S12e/Gadd45 family