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    alh-12 Aldehyde dehydrogenase domain-containing protein [ Caenorhabditis elegans ]

    Gene ID: 176056, updated on 2-Nov-2024

    Summary

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    Official Symbol
    alh-12
    Official Full Name
    Aldehyde dehydrogenase domain-containing protein
    Primary source
    WormBase:WBGene00000118
    Locus tag
    CELE_Y69F12A.2
    See related
    AllianceGenome:WB:WBGene00000118
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Predicted to enable 4-trimethylammoniobutyraldehyde dehydrogenase activity and aminobutyraldehyde dehydrogenase (NAD+) activity. Orthologous to human ALDH9A1 (aldehyde dehydrogenase 9 family member A1). [provided by Alliance of Genome Resources, Nov 2024]
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    Genomic context

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    See alh-12 in Genome Data Viewer
    Location:
    chromosome: III
    Exon count:
    3
    Sequence:
    Chromosome: III; NC_003281.10 (7454074..7455936)

    Chromosome III - NC_003281.10Genomic Context describing neighboring genes Neighboring gene ncRNA Neighboring gene Ligand-gated ion channel 50 Neighboring gene ncRNA Neighboring gene Protein kinase domain-containing protein Neighboring gene FIP (Fungus-Induced Protein) Related

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003281.10

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Targeting Mitochondrial Network Disorganization is Protective in C. elegans Models of Huntington's Disease. Machiela E, et al. Aging Dis, 2021 Oct. PMID 34631219, Free PMC Article
    2. The embryonic muscle transcriptome of Caenorhabditis elegans. Fox RM, et al. Genome Biol, 2007. PMID 17848203, Free PMC Article
    3. Proteomic analysis of protein expression profiles during Caenorhabditis elegans development using two-dimensional difference gel electrophoresis. Tabuse Y, et al. Proteomics, 2005 Jul. PMID 15996007
    4. Comparative genomics and functional study of lipid metabolic genes in Caenorhabditis elegans. Zhang Y, et al. BMC Genomics, 2013 Mar 12. PMID 23496871, Free PMC Article
    5. Depletion of endogenously biotinylated carboxylases enhances the sensitivity of TurboID-mediated proximity labeling in Caenorhabditis elegans. Artan M, et al. J Biol Chem, 2022 Sep. PMID 35933017, Free PMC Article

    See all (10) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables 4-trimethylammoniobutyraldehyde dehydrogenase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables aminobutyraldehyde dehydrogenase (NAD+) activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables oxidoreductase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    Aldehyde dehydrogenase domain-containing protein
    NP_001022930.1
    • Confirmed by transcript evidence
    NP_001370775.1
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003281.10 Reference assembly

      Range
      7454074..7455936
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001382916.1 → NP_001370775.1  Aldehyde dehydrogenase domain-containing protein [Caenorhabditis elegans]

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q7Z1Q2
      Conserved Domains (1) summary
      cl11961
      Location:31 → 430
      ALDH-SF; NAD(P)+-dependent aldehyde dehydrogenase superfamily

    2. NM_001027759.4 → NP_001022930.1  Aldehyde dehydrogenase domain-containing protein [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_001022930.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q7Z1Q3
      Conserved Domains (1) summary
      cd07090
      Location:31 → 492
      ALDH_F9_TMBADH; NAD+-dependent 4-trimethylaminobutyraldehyde dehydrogenase, ALDH family 9A1
    Nucleotide Protein
    Heading Accession and Version

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