cdf-2 Zinc transporter 2 [Caenorhabditis elegans] - Gene

Summary

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Official Symbol: cdf-2
Official Full Name: Zinc transporter 2
Primary source: WormBase:WBGene00011821
Locus tag: CELE_T18D3.3
See related: AllianceGenome:WB:WBGene00011821
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Caenorhabditis elegans (strain: Bristol N2)
Lineage: Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary: Predicted to enable monoatomic cation transmembrane transporter activity. Involved in cellular response to zinc ion and zinc ion transmembrane transport. Located in gut granule membrane. Is expressed in intestine. Human ortholog(s) of this gene implicated in type 2 diabetes mellitus. Orthologous to several human genes including SLC30A8 (solute carrier family 30 member 8). [provided by Alliance of Genome Resources, Nov 2024]
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Genomic context

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See cdf-2 in Genome Data Viewer

Location:: chromosome: X

Exon count:: 8

Sequence:: Chromosome: X; NC_003284.9 (12464640..12466917, complement)

Chromosome X - NC_003284.9 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_003284.9

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

identify cdf-2 as a new gene that has a critical role in zinc storage
Title: The cation diffusion facilitator gene cdf-2 mediates zinc metabolism in Caenorhabditis elegans.

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

T18D3.3 (e-PCR)
- UniSTS:315009

Homology

Orthologs from OrthoDB

Gene Ontology Provided by WormBase

Function	Evidence Code	Pubs
enables monoatomic cation transmembrane transporter activity	IEA Inferred from Electronic Annotation more info
enables zinc ion transmembrane transporter activity	IBA Inferred from Biological aspect of Ancestor more info

Process	Evidence Code	Pubs
involved_in cellular response to zinc ion	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in monoatomic cation transport	IEA Inferred from Electronic Annotation more info
involved_in response to zinc ion	IBA Inferred from Biological aspect of Ancestor more info
involved_in transmembrane transport	IEA Inferred from Electronic Annotation more info
involved_in zinc ion transmembrane transport	IBA Inferred from Biological aspect of Ancestor more info
involved_in zinc ion transmembrane transport	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
located_in gut granule membrane	IDA Inferred from Direct Assay more info	PubMed
located_in membrane	IEA Inferred from Electronic Annotation more info
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: Zinc transporter 2

NP_001300381.1

Confirmed by transcript evidence

NP_510091.2

Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_003284.9 Reference assembly

Range

12464640..12466917 complement

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_077690.4 → NP_510091.2 Zinc transporter 2 [Caenorhabditis elegans]

See identical proteins and their annotated locations for NP_510091.2

Status: REVIEWED

UniProtKB/TrEMBL

Q22541

Conserved Domains (3) summary

TIGR01297
Location:63 → 343

CDF; cation diffusion facilitator family transporter

pfam01545
Location:64 → 266

Cation_efflux; Cation efflux family

pfam16916
Location:276 → 343

ZT_dimer; Dimerization domain of Zinc Transporter
NM_001313452.1 → NP_001300381.1 Zinc transporter 2 [Caenorhabditis elegans]

Status: REVIEWED

UniProtKB/TrEMBL

A0A0K3AVP5

Conserved Domains (1) summary

TIGR01297
Location:1 → 43

CDF; cation diffusion facilitator family transporter