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    gskl-1 Protein kinase domain-containing protein;Putative serine/threonine-protein kinase R03D7.5 [ Caenorhabditis elegans ]

    Gene ID: 187536, updated on 9-Dec-2024

    Summary

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    Official Symbol
    gskl-1
    Official Full Name
    Protein kinase domain-containing protein;Putative serine/threonine-protein kinase R03D7.5
    Primary source
    WormBase:WBGene00010991
    Locus tag
    CELE_R03D7.5
    See related
    AllianceGenome:WB:WBGene00010991
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Predicted to enable protein serine/threonine kinase activity. Predicted to be involved in several processes, including negative regulation of canonical Wnt signaling pathway; positive regulation of proteasomal ubiquitin-dependent protein catabolic process; and regulation of microtubule cytoskeleton organization. Predicted to be active in axon; cytosol; and nucleus. Is expressed in germ line; gonad; sperm; spermatocyte; and in male. [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See gskl-1 in Genome Data Viewer
    Location:
    chromosome: II
    Exon count:
    8
    Sequence:
    Chromosome: II; NC_003280.10 (10947559..10949263)

    Chromosome II - NC_003280.10Genomic Context describing neighboring genes Neighboring gene pseudo Neighboring gene Phage protein Neighboring gene Transcription elongation factor B polypeptide 3 Neighboring gene GST C-terminal domain-containing protein;putative glutathione S-transferase 5 Neighboring gene Nanos-type domain-containing protein Neighboring gene Serine/threonine specific protein phosphatases domain-containing protein

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003280.10

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Sperm-specific glycogen synthase kinase 3 is required for sperm motility and the post-fertilization signal for female meiosis II in Caenorhabditis elegans. Banerjee RP, et al. Development, 2022 May 15. PMID 35635101
    2. Genomic overview of protein kinases. Manning G. WormBook, 2005 Dec 13. PMID 18050405, Free PMC Article
    3. Genome sequence of the nematode C. elegans: a platform for investigating biology. C. elegans Sequencing Consortium. Science, 1998 Dec 11. PMID 9851916

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein serine kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein serine/threonine kinase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables protein serine/threonine kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in cell differentiation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in negative regulation of canonical Wnt signaling pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in positive regulation of proteasomal ubiquitin-dependent protein catabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in protein phosphorylation IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in regulation of microtubule cytoskeleton organization IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in signal transduction IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in axon IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in cytosol IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    Protein kinase domain-containing protein;Putative serine/threonine-protein kinase R03D7.5
    NP_001300575.1
    • Confirmed by transcript evidence
    NP_496356.2
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003280.10 Reference assembly

      Range
      10947559..10949263
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_063955.4 → NP_496356.2  Putative serine/threonine-protein kinase R03D7.5 [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_496356.2

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q09595
      Conserved Domains (2) summary
      smart00220
      Location:23 → 304
      S_TKc; Serine/Threonine protein kinases, catalytic domain
      cl21453
      Location:15 → 307
      PKc_like; Protein Kinases, catalytic domain

    2. NM_001313646.1 → NP_001300575.1  Protein kinase domain-containing protein [Caenorhabditis elegans]

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A0K3AR32
      Conserved Domains (1) summary
      cl21453
      Location:8 → 33
      PKc_like; Protein Kinases, catalytic domain
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q09595.2

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