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    slt-1 Slit homolog 1 protein [ Caenorhabditis elegans ]

    Gene ID: 181562, updated on 9-Dec-2024

    Summary

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    Official Symbol
    slt-1
    Official Full Name
    Slit homolog 1 protein
    Primary source
    WormBase:WBGene00004854
    Locus tag
    CELE_F40E10.4
    See related
    AllianceGenome:WB:WBGene00004854
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Enables signaling receptor binding activity. Involved in axon guidance; neuron migration; and regulation of neuron projection development. Predicted to be located in extracellular region. Is expressed in anal sphincter muscle; anterior hypodermis; body wall musculature; nerve ring neurons; and socket cell. Orthologous to human SLIT1 (slit guidance ligand 1); SLIT2 (slit guidance ligand 2); and SLIT3 (slit guidance ligand 3). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See slt-1 in Genome Data Viewer
    Location:
    chromosome: X
    Exon count:
    32
    Sequence:
    Chromosome: X; NC_003284.9 (14674328..14683324)

    Chromosome X - NC_003284.9Genomic Context describing neighboring genes Neighboring gene Hyphal_reg_CWP domain-containing protein Neighboring gene ncRNA Neighboring gene tRNA-Ile Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene Calsequestrin

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003284.9

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. The ANC-1 (Nesprin-1/2) organelle-anchoring protein functions through mitochondria to polarize axon growth in response to SLT-1. Fischer NC, et al. PLoS Genet, 2022 Nov. PMID 36409768, Free PMC Article
    2. mau-2 acts cell-autonomously to guide axonal migrations in Caenorhabditis elegans. Bénard CY, et al. Development, 2004 Dec. PMID 15539489
    3. The Caenorhabditis elegans NF2/Merlin Molecule NFM-1 Nonautonomously Regulates Neuroblast Migration and Interacts Genetically with the Guidance Cue SLT-1/Slit. Josephson MP, et al. Genetics, 2017 Feb. PMID 27913619, Free PMC Article
    4. The C. elegans CDK8 Mediator module regulates axon guidance decisions in the ventral nerve cord and during dorsal axon navigation. Steimel A, et al. Dev Biol, 2013 May 15. PMID 23458898
    5. UNC-6/netrin and SLT-1/slit guidance cues orient axon outgrowth mediated by MIG-10/RIAM/lamellipodin. Quinn CC, et al. Curr Biol, 2006 May 9. PMID 16563765

    See all (58) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. these observations suggest that MIG-10 interacts with ABI-1 and WVE-1 to mediate the UNC-6 and SLT-1 guidance pathways.
      Title: MIG-10 functions with ABI-1 to mediate the UNC-6 and SLT-1 axon guidance signaling pathways.
    2. EVA-1 identified as a transmembrane receptor for SLT-1; EVA-1 acts cell-autonomously for SLT-1/Slit-dependent axon migration functions of SAX-3/Robo, colocalizes with SAX-3 on cells & provides cell specificity to activation of SAX-3 signaling by SLT-1
      Title: The slit receptor EVA-1 coactivates a SAX-3/Robo mediated guidance signal in C. elegans.
    3. Genetic analyses indicate that MIG-10/RIAM/lamellipodin, a cytoplasmic adaptor protein, functions downstream of the repulsive guidance cue SLT-1/slit to direct the ventral migration of the AVM and PVM axons in C. elegans.
      Title: UNC-6/netrin and SLT-1/slit guidance cues orient axon outgrowth mediated by MIG-10/RIAM/lamellipodin.
    Submit: New GeneRIF Correction

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables Roundabout binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables calcium ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables heparin binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables signaling receptor binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables signaling receptor binding ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in axon guidance IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in axon midline choice point recognition IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in cellular component organization IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in dorsal/ventral axon guidance IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in dorsal/ventral axon guidance IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in negative regulation of axon extension involved in axon guidance IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in nervous system development IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in neuron migration IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in regulation of sensory neuron axon guidance IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in sensory neuron axon guidance IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in extracellular region IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in extracellular region ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    Slit homolog 1 protein
    NP_510437.2
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003284.9 Reference assembly

      Range
      14674328..14683324
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_078036.8 → NP_510437.2  Slit homolog 1 protein [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_510437.2

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      G5EFX6
      Conserved Domains (9) summary
      smart00013
      Location:259 → 291
      LRRNT; Leucine rich repeat N-terminal domain
      smart00041
      Location:1334 → 1405
      CT; C-terminal cystine knot-like domain (CTCK)
      smart00082
      Location:195 → 243
      LRRCT; Leucine rich repeat C-terminal domain
      smart00282
      Location:1133 → 1268
      LamG; Laminin G domain
      cd00054
      Location:947 → 983
      EGF_CA; Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the ...
      cd00116
      Location:514 → 635
      LRR_RI; Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond ...
      sd00033
      Location:48 → 69
      LRR_RI; leucine-rich repeat [structural motif]
      pfam12799
      Location:311 → 352
      LRR_4; Leucine Rich repeats (2 copies)
      pfam13855
      Location:729 → 788
      LRR_8; Leucine rich repeat
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    G5EFX6.1

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