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    copb-1 Coatomer subunit beta [ Caenorhabditis elegans ]

    Gene ID: 173656, updated on 2-Nov-2024

    Summary

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    Official Symbol
    copb-1
    Official Full Name
    Coatomer subunit beta
    Primary source
    WormBase:WBGene00021292
    Locus tag
    CELE_Y25C1A.5
    See related
    AllianceGenome:WB:WBGene00021292
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Predicted to enable structural molecule activity. Predicted to be involved in endoplasmic reticulum to Golgi vesicle-mediated transport and intra-Golgi vesicle-mediated transport. Predicted to be located in COPI-coated vesicle membrane and Golgi membrane. Predicted to be part of COPI vesicle coat. Is expressed in several structures, including enteric muscle; excretory cell; intestine; pharynx; and vulval muscle. Orthologous to human COPB1 (COPI coat complex subunit beta 1). [provided by Alliance of Genome Resources, Nov 2024]
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    Genomic context

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    See copb-1 in Genome Data Viewer
    Location:
    chromosome: II
    Exon count:
    7
    Sequence:
    Chromosome: II; NC_003280.10 (3078796..3087682)

    Chromosome II - NC_003280.10Genomic Context describing neighboring genes Neighboring gene Protein YIPF;Yip1 domain-containing protein Neighboring gene Zinc finger Ran-binding domain-containing protein 2 Neighboring gene ncRNA Neighboring gene Serpentine receptor class gamma Neighboring gene Serpentine receptor class gamma

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003280.10

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. AP-1 Recruits SMAP-1/SMAPs to the trans-Golgi Network to Promote Sorting in Polarized Epithelia. Wang S, et al. Front Cell Dev Biol, 2021. PMID 34901019, Free PMC Article
    2. The small GTPase Arf1 modulates mitochondrial morphology and function. Ackema KB, et al. EMBO J, 2014 Nov 18. PMID 25190516, Free PMC Article
    3. A Sterile 20 Family Kinase and Its Co-factor CCM-3 Regulate Contractile Ring Proteins on Germline Intercellular Bridges. Rehain-Bell K, et al. Curr Biol, 2017 Mar 20. PMID 28285996, Free PMC Article
    4. Robust co-immunoprecipitation with mass spectrometry for Caenorhabditis elegans using solid-phase enhanced sample preparation. Baytek G, et al. Biotechniques, 2022 May. PMID 35297663
    5. Dissection of the mammalian midbody proteome reveals conserved cytokinesis mechanisms. Skop AR, et al. Science, 2004 Jul 2. PMID 15166316, Free PMC Article

    See all (17) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables structural molecule activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in endoplasmic reticulum to Golgi vesicle-mediated transport IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in intra-Golgi vesicle-mediated transport IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in intracellular protein transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in protein transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in vesicle-mediated transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    part_of COPI vesicle coat IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of COPI vesicle coat IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in COPI-coated vesicle membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in Golgi apparatus IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in Golgi membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytoplasmic vesicle IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    part_of membrane coat IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    Coatomer subunit beta
    NP_494441.1
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003280.10 Reference assembly

      Range
      3078796..3087682
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_062040.9 → NP_494441.1  Coatomer subunit beta [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_494441.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q9TYL9
      Conserved Domains (4) summary
      COG5096
      Location:31 → 935
      COG5096; Vesicle coat complex, various subunits [Intracellular trafficking, secretion, and vesicular transport]
      pfam07718
      Location:677 → 816
      Coatamer_beta_C; Coatomer beta C-terminal region
      pfam14806
      Location:825 → 953
      Coatomer_b_Cpla; Coatomer beta subunit appendage platform
      sd00044
      Location:138 → 162
      HEAT; HEAT repeat [structural motif]
    Nucleotide Protein
    Heading Accession and Version

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