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    tyra-2 Tyramine receptor tyra-2 [ Caenorhabditis elegans ]

    Gene ID: 180970, updated on 9-Dec-2024

    Summary

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    Official Symbol
    tyra-2
    Official Full Name
    Tyramine receptor tyra-2
    Primary source
    WormBase:WBGene00017157
    Locus tag
    CELE_F01E11.5
    See related
    AllianceGenome:WB:WBGene00017157
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Predicted to enable G protein-coupled amine receptor activity. Predicted to be involved in adenylate cyclase-activating adrenergic receptor signaling pathway and positive regulation of MAPK cascade. Predicted to be located in membrane. Predicted to be active in plasma membrane. Is expressed in neurons. [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See tyra-2 in Genome Data Viewer
    Location:
    chromosome: X
    Exon count:
    14
    Sequence:
    Chromosome: X; NC_003284.9 (6996853..7005575, complement)

    Chromosome X - NC_003284.9Genomic Context describing neighboring genes Neighboring gene ncRNA Neighboring gene glucuronosyltransferase Neighboring gene Tetraspanin Neighboring gene Uncharacterized protein Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003284.9

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Are Caenorhabditis elegans receptors useful targets for drug discovery: pharmacological comparison of tyramine receptors with high identity from C. elegans (TYRA-2) and Brugia malayi (Bm4). Smith KA, et al. Mol Biochem Parasitol, 2007 Jul. PMID 17537528, Free PMC Article
    2. Co-option of neurotransmitter signaling for inter-organismal communication in C. elegans. Chute CD, et al. Nat Commun, 2019 Jul 18. PMID 31320626, Free PMC Article
    3. AIM interneurons mediate feeding suppression through the TYRA-2 receptor in C. elegans. Fu J, et al. Biophys Rep, 2018. PMID 29577066, Free PMC Article
    4. TYRA-2 (F01E11.5): a Caenorhabditis elegans tyramine receptor expressed in the MC and NSM pharyngeal neurons. Rex E, et al. J Neurochem, 2005 Jul. PMID 15953361
    5. Methylglyoxal-derived hydroimidazolone, MG-H1, increases food intake by altering tyramine signaling via the GATA transcription factor ELT-3 in Caenorhabditis elegans. Muthaiyan Shanmugam M, et al. Elife, 2023 Sep 20. PMID 37728328, Free PMC Article

    See all (20) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables G protein-coupled amine receptor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables G protein-coupled receptor activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables signaling receptor activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in G protein-coupled receptor signaling pathway IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in response to stimulus IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in plasma membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    Tyramine receptor tyra-2
    NP_001024521.1
    • Confirmed by transcript evidence
    NP_001024522.1
    • Confirmed by transcript evidence
    NP_001033537.1
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003284.9 Reference assembly

      Range
      6996853..7005575 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001029350.7 → NP_001024521.1  Tyramine receptor tyra-2 [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_001024521.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q19084
      Conserved Domains (1) summary
      pfam00001
      Location:36 → 235
      7tm_1; 7 transmembrane receptor (rhodopsin family)

    2. NM_001038448.5 → NP_001033537.1  Tyramine receptor tyra-2 [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_001033537.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q19084, Q3S1M1, Q7Z290
      Conserved Domains (1) summary
      pfam00001
      Location:36 → 232
      7tm_1; 7 transmembrane receptor (rhodopsin family)

    3. NM_001029351.6 → NP_001024522.1  Tyramine receptor tyra-2 [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_001024522.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q19084
      Conserved Domains (1) summary
      pfam00001
      Location:217 → 315
      7tm_1; 7 transmembrane receptor (rhodopsin family)
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q19084.3

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