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    slc-25A29 Mitochondrial carnitine/acylcarnitine carrier protein CACL [ Caenorhabditis elegans ]

    Gene ID: 179969, updated on 9-Dec-2024

    Summary

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    Official Symbol
    slc-25A29
    Official Full Name
    Mitochondrial carnitine/acylcarnitine carrier protein CACL
    Primary source
    WormBase:WBGene00008320
    Locus tag
    CELE_C54G10.4
    See related
    AllianceGenome:WB:WBGene00008320
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Predicted to enable high-affinity L-arginine transmembrane transporter activity and high-affinity lysine transmembrane transporter activity. Predicted to be involved in mitochondrial L-ornithine transmembrane transport. Predicted to be located in membrane. Predicted to be active in mitochondrion. Orthologous to human SLC25A29 (solute carrier family 25 member 29). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See slc-25A29 in Genome Data Viewer
    Location:
    chromosome: V
    Exon count:
    8
    Sequence:
    Chromosome: V; NC_003283.11 (14653489..14658175, complement)

    Chromosome V - NC_003283.11Genomic Context describing neighboring genes Neighboring gene Uncharacterized protein Neighboring gene Replication factor C subunit 1 Neighboring gene ATP-binding cassette sub-family D member 4 Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene Serpentine Receptor, class H Neighboring gene Secreted protein

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003283.11

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Defective arginine metabolism impairs mitochondrial homeostasis in Caenorhabditiselegans. Tang R, et al. J Genet Genomics, 2020 Mar 20. PMID 32305173
    2. Transcriptomics of ivermectin response in Caenorhabditis elegans: Integrating abamectin quantitative trait loci and comparison to the Ivermectin-exposed DA1316 strain. Dube F, et al. PLoS One, 2023. PMID 37141255, Free PMC Article
    3. OrthoList: a compendium of C. elegans genes with human orthologs. Shaye DD, et al. PLoS One, 2011. PMID 21647448, Free PMC Article
    4. OrthoList 2: A New Comparative Genomic Analysis of Human and Caenorhabditis elegans Genes. Kim W, et al. Genetics, 2018 Oct. PMID 30120140, Free PMC Article
    5. Genome sequence of the nematode C. elegans: a platform for investigating biology. C. elegans Sequencing Consortium. Science, 1998 Dec 11. PMID 9851916

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    prim_transcript

    • Loc: c14656636-14656500 standard_name = C54G10.6.1

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables high-affinity L-arginine transmembrane transporter activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables high-affinity lysine transmembrane transporter activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in L-arginine transmembrane transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in mitochondrial L-ornithine transmembrane transport IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in mitochondrion IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    Mitochondrial carnitine/acylcarnitine carrier protein CACL
    NP_001294735.1
    • Confirmed by transcript evidence
    NP_001379141.1
    • Confirmed by transcript evidence
    NP_872134.1
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003283.11 Reference assembly

      Range
      14653489..14658175 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001392659.1 → NP_001379141.1  Mitochondrial carnitine/acylcarnitine carrier protein CACL [Caenorhabditis elegans]

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q18844
      Conserved Domains (1) summary
      pfam00153
      Location:91 → 186
      Mito_carr; Mitochondrial carrier protein

    2. NM_182334.4 → NP_872134.1  Mitochondrial carnitine/acylcarnitine carrier protein CACL [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_872134.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q8I4M0
      Conserved Domains (2) summary
      PTZ00169
      Location:1 → 258
      PTZ00169; ADP/ATP transporter on adenylate translocase; Provisional
      pfam00153
      Location:91 → 186
      Mito_carr; Mitochondrial carrier protein

    3. NM_001307806.4 → NP_001294735.1  Mitochondrial carnitine/acylcarnitine carrier protein CACL [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_001294735.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      M1ZJU4
      Conserved Domains (2) summary
      PTZ00169
      Location:1 → 258
      PTZ00169; ADP/ATP transporter on adenylate translocase; Provisional
      pfam00153
      Location:91 → 186
      Mito_carr; Mitochondrial carrier protein
    Nucleotide Protein
    Heading Accession and Version

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