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    nhr-57 Nuclear hormone receptor family member nhr-57 [ Caenorhabditis elegans ]

    Gene ID: 178813, updated on 9-Dec-2024

    Summary

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    Official Symbol
    nhr-57
    Official Full Name
    Nuclear hormone receptor family member nhr-57
    Primary source
    WormBase:WBGene00003647
    Locus tag
    CELE_T05B4.2
    See related
    AllianceGenome:WB:WBGene00003647
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Predicted to enable DNA-binding transcription factor activity. Involved in response to hypoxia. Predicted to be active in nucleus. Is expressed in several structures, including cephalic sheath cell; ciliated neurons; excretory system; intestine; and vulva. [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See nhr-57 in Genome Data Viewer
    Location:
    chromosome: V
    Exon count:
    8
    Sequence:
    Chromosome: V; NC_003283.11 (4131889..4135102)

    Chromosome V - NC_003283.11Genomic Context describing neighboring genes Neighboring gene pseudo Neighboring gene ncRNA Neighboring gene ShKT domain-containing protein Neighboring gene Neur_chan_LBD domain-containing protein Neighboring gene Neurotransmitter-gated ion-channel ligand-binding domain-containing protein Neighboring gene Late endosomal/lysosomal adaptor and MAPK and MTOR activator 1 Neighboring gene Activin_recp domain-containing protein;Protein sleepless

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003283.11

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Hypoxia and the hypoxic response pathway protect against pore-forming toxins in C. elegans. Bellier A, et al. PLoS Pathog, 2009 Dec. PMID 20011506, Free PMC Article
    2. Cobalt chloride has beneficial effects across species through a hormetic mechanism. Schiavi A, et al. Front Cell Dev Biol, 2022. PMID 36393859, Free PMC Article
    3. CYSL-1 interacts with the O2-sensing hydroxylase EGL-9 to promote H2S-modulated hypoxia-induced behavioral plasticity in C. elegans. Ma DK, et al. Neuron, 2012 Mar 8. PMID 22405203, Free PMC Article
    4. Disruption of mitochondrial dynamics increases stress resistance through activation of multiple stress response pathways. Machiela E, et al. FASEB J, 2020 Jun. PMID 32385951, Free PMC Article
    5. The hypoxia-response pathway modulates RAS/MAPK-mediated cell fate decisions in Caenorhabditis elegans. Maxeiner S, et al. Life Sci Alliance, 2019 Jun. PMID 31126994, Free PMC Article

    See all (16) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables DNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables DNA-binding transcription factor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables DNA-binding transcription factor activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables sequence-specific DNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables zinc ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in innate immune response HEP PubMed 
    involved_in regulation of DNA-templated transcription IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in regulation of transcription by RNA polymerase II IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in response to hypoxia IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in response to hypoxia IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    Nuclear hormone receptor family member nhr-57
    NP_504153.1
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003283.11 Reference assembly

      Range
      4131889..4135102
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_071752.8 → NP_504153.1  Nuclear hormone receptor family member nhr-57 [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_504153.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      O16425
      UniProtKB/TrEMBL
      Q9BJK9
      Conserved Domains (2) summary
      smart00399
      Location:10 → 80
      ZnF_C4; c4 zinc finger in nuclear hormone receptors
      pfam00104
      Location:153 → 350
      Hormone_recep; Ligand-binding domain of nuclear hormone receptor
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    O16425.1

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