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    rcs-1 RING-type domain-containing protein [ Caenorhabditis elegans ]

    Gene ID: 259719, updated on 9-Dec-2024

    Summary

    Official Symbol
    rcs-1
    Official Full Name
    RING-type domain-containing protein
    Primary source
    WormBase:WBGene00016190
    Locus tag
    CELE_C28G1.5
    See related
    AllianceGenome:WB:WBGene00016190
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Predicted to enable zinc ion binding activity. Is expressed in intestine. Human ortholog(s) of this gene implicated in several diseases, including Henoch-Schoenlein purpura; Sweet syndrome; asthma; familial Mediterranean fever; and hematologic cancer (multiple). Orthologous to several human genes including BSPRY (B-box and SPRY domain containing); MEFV (MEFV innate immunity regulator, pyrin); and RNF39 (ring finger protein 39). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

    See rcs-1 in Genome Data Viewer
    Location:
    chromosome: X
    Exon count:
    7
    Sequence:
    Chromosome: X; NC_003284.9 (8826604..8828540, complement)

    Chromosome X - NC_003284.9Genomic Context describing neighboring genes Neighboring gene tRNA-Gly Neighboring gene Intermediate filament protein ifd-1 Neighboring gene RING-type domain-containing protein Neighboring gene ncRNA Neighboring gene Exocyst complex component 6

    Interactions

    General gene information

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables metal ion binding  
    enables zinc ion binding  

    General protein information

    Preferred Names
    RING-type domain-containing protein
    NP_001123114.1
    • Confirmed by transcript evidence
    NP_001361935.1
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003284.9 Reference assembly

      Range
      8826604..8828540 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001129642.5NP_001123114.1  RING-type domain-containing protein [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_001123114.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      A8WFJ8
      Conserved Domains (2) summary
      cd16516
      Location:551
      RING-HC_malin; RING finger, HC subclass, found in malin and similar proteins
      cl00034
      Location:94143
      Bbox_SF; B-box-type zinc finger superfamily
    2. NM_001375093.1NP_001361935.1  RING-type domain-containing protein [Caenorhabditis elegans]

      Status: REVIEWED

      UniProtKB/TrEMBL
      H2KYH9
      Conserved Domains (1) summary
      cd16516
      Location:551
      RING-HC_malin; RING finger, HC subclass, found in malin and similar proteins
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