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    sym-4 WD repeat-containing protein 44 [ Caenorhabditis elegans ]

    Gene ID: 181527, updated on 9-Dec-2024

    Summary

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    Official Symbol
    sym-4
    Official Full Name
    WD repeat-containing protein 44
    Primary source
    WormBase:WBGene00006369
    Locus tag
    CELE_R03E1.1
    See related
    AllianceGenome:WB:WBGene00006369
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Is expressed in several structures, including anal depressor muscle; coelomocyte; nervous system; rectum; and reproductive system. Orthologous to human WDR44 (WD repeat domain 44). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See sym-4 in Genome Data Viewer
    Location:
    chromosome: X
    Exon count:
    10
    Sequence:
    Chromosome: X; NC_003284.9 (14164640..14169619, complement)

    Chromosome X - NC_003284.9Genomic Context describing neighboring genes Neighboring gene tRNA-Ser Neighboring gene ncRNA Neighboring gene Vacuolar H ATPase Neighboring gene putative isocitrate dehydrogenase [NAD] subunit beta, mitochondrial Neighboring gene FAR-17a/AIG1-like protein

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003284.9

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. FBN-1, a fibrillin-related protein, is required for resistance of the epidermis to mechanical deformation during C. elegans embryogenesis. Kelley M, et al. Elife, 2015 Mar 23. PMID 25798732, Free PMC Article
    2. Effectors of anterior morphogenesis in C. elegans embryos. Balasubramaniam B, et al. Biol Open, 2023 Jul 15. PMID 37345480, Free PMC Article
    3. The identities of sym-2, sym-3 and sym-4, three genes that are synthetically lethal with mec-8 in Caenorhabditis elegans. Yochem J, et al. Genetics, 2004 Nov. PMID 15579686, Free PMC Article
    4. Functional overlap between the mec-8 gene and five sym genes in Caenorhabditis elegans. Davies AG, et al. Genetics, 1999 Sep. PMID 10471705, Free PMC Article
    5. Depletion of endogenously biotinylated carboxylases enhances the sensitivity of TurboID-mediated proximity labeling in Caenorhabditis elegans. Artan M, et al. J Biol Chem, 2022 Sep. PMID 35933017, Free PMC Article

    See all (9) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    General protein information

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    Preferred Names
    WD repeat-containing protein 44
    NP_510361.1
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003284.9 Reference assembly

      Range
      14164640..14169619 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_077960.8 → NP_510361.1  WD repeat-containing protein 44 [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_510361.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      G5EEV4
      Conserved Domains (3) summary
      COG2319
      Location:603 → 919
      WD40; WD40 repeat [General function prediction only]
      sd00039
      Location:721 → 755
      7WD40; WD40 repeat [structural motif]
      cl02567
      Location:614 → 920
      WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
    Nucleotide Protein
    Heading Accession and Version

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