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    dao-3 methenyltetrahydrofolate cyclohydrolase [ Caenorhabditis elegans ]

    Gene ID: 181065, updated on 9-Dec-2024

    Summary

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    Official Symbol
    dao-3
    Official Full Name
    methenyltetrahydrofolate cyclohydrolase
    Primary source
    WormBase:WBGene00000929
    Locus tag
    CELE_K07E3.3
    See related
    AllianceGenome:WB:WBGene00000929
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Predicted to enable methenyltetrahydrofolate cyclohydrolase activity and methylenetetrahydrofolate dehydrogenase (NADP+) activity. Predicted to be involved in tetrahydrofolate interconversion. Predicted to be active in cytosol. Is expressed in hypodermis and nervous system. Orthologous to several human genes including MTHFD2 (methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 2, methenyltetrahydrofolate cyclohydrolase). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See dao-3 in Genome Data Viewer
    Location:
    chromosome: X
    Exon count:
    5
    Sequence:
    Chromosome: X; NC_003284.9 (8084210..8086550, complement)

    Chromosome X - NC_003284.9Genomic Context describing neighboring genes Neighboring gene Secreted protein Neighboring gene formate--tetrahydrofolate ligase Neighboring gene Protein vem-1 Neighboring gene Cation-transporting ATPase;Cation-transporting ATPase catp-5 Neighboring gene ncRNA

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003284.9

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Loss of the histone chaperone UNC-85/ASF1 inhibits the epigenome-mediated longevity and modulates the activity of one-carbon metabolism. Shrestha B, et al. Cell Stress Chaperones, 2024 Jun. PMID 38608859, Free PMC Article
    2. DAF-16-dependent and independent expression targets of DAF-2 insulin receptor-like pathway in Caenorhabditis elegans include FKBPs. Yu H, et al. J Mol Biol, 2001 Dec 14. PMID 11743719
    3. Regulation of the one carbon folate cycle as a shared metabolic signature of longevity. Annibal A, et al. Nat Commun, 2021 Jun 9. PMID 34108489, Free PMC Article
    4. H3K9me1/2 methylation limits the lifespan of daf-2 mutants in C. elegans. Huang M, et al. Elife, 2022 Sep 20. PMID 36125117, Free PMC Article
    5. Reduced bone morphogenic protein signaling along the gut-neuron axis by heat shock factor promotes longevity. Arneaud SLB, et al. Aging Cell, 2022 Sep. PMID 35977034, Free PMC Article

    See all (15) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables hydrolase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables methenyltetrahydrofolate cyclohydrolase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables methenyltetrahydrofolate cyclohydrolase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables methylenetetrahydrofolate dehydrogenase (NADP+) activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables methylenetetrahydrofolate dehydrogenase (NADP+) activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables oxidoreductase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in one-carbon metabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in tetrahydrofolate interconversion IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cytosol IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    methenyltetrahydrofolate cyclohydrolase
    NP_509362.1
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003284.9 Reference assembly

      Range
      8084210..8086550 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_076961.7 → NP_509362.1  methenyltetrahydrofolate cyclohydrolase [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_509362.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q21285
      Conserved Domains (3) summary
      cd01080
      Location:119 → 291
      NAD_bind_m-THF_DH_Cyclohyd; NADP binding domain of methylene-tetrahydrofolate dehydrogenase/cyclohydrolase
      COG0190
      Location:5 → 294
      FolD; 5,10-methylene-tetrahydrofolate dehydrogenase/Methenyl tetrahydrofolate cyclohydrolase [Coenzyme transport and metabolism]
      pfam00763
      Location:5 → 124
      THF_DHG_CYH; Tetrahydrofolate dehydrogenase/cyclohydrolase, catalytic domain
    Nucleotide Protein
    Heading Accession and Version

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