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    cdc-25.4 M-phase inducer phosphatase [ Caenorhabditis elegans ]

    Gene ID: 191612, updated on 9-Dec-2024

    Summary

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    Official Symbol
    cdc-25.4
    Official Full Name
    M-phase inducer phosphatase
    Primary source
    WormBase:WBGene00000389
    Locus tag
    CELE_R05H5.2
    See related
    AllianceGenome:WB:WBGene00000389
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Predicted to enable protein tyrosine phosphatase activity. Predicted to be involved in G2/M transition of mitotic cell cycle; positive regulation of G2/M transition of mitotic cell cycle; and positive regulation of G2/MI transition of meiotic cell cycle. Predicted to be active in cytoplasm and nucleus. Is expressed in several structures, including ganglia; germ line; pharyngeal cell; ventral nerve cord; and in male. [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See cdc-25.4 in Genome Data Viewer
    Location:
    chromosome: II
    Exon count:
    6
    Sequence:
    Chromosome: II; NC_003280.10 (10188258..10189469, complement)

    Chromosome II - NC_003280.10Genomic Context describing neighboring genes Neighboring gene Serpentine receptor class delta-1 Neighboring gene ncRNA Neighboring gene Serpentine receptor class delta-2 Neighboring gene WAP domain-containing protein Neighboring gene Serpentine receptor class beta-6

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003280.10

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. cdc-25.4, a Caenorhabditis elegans Ortholog of cdc25, Is Required for Male Mating Behavior. Oh S, et al. G3 (Bethesda), 2016 Dec 7. PMID 27770028, Free PMC Article
    2. Identification of cdc25 gene in pinewood nematode, Bursaphelenchus xylophilus, and its function in reproduction. Choi YN, et al. Mol Cells, 2010 Feb 28. PMID 20069382
    3. CDC-25.1 regulates germline proliferation in Caenorhabditis elegans. Ashcroft N, et al. Genesis, 2002 May. PMID 12001064
    4. The four cdc25 genes from the nematode Caenorhabditis elegans. Ashcroft NR, et al. Gene, 1998 Jul 3. PMID 9651482
    5. Cell-cycle regulation. van den Heuvel S. WormBook, 2005 Sep 21. PMID 18050422, Free PMC Article

    See all (8) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables phosphoprotein phosphatase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein tyrosine phosphatase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables protein tyrosine phosphatase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in G2/M transition of mitotic cell cycle IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in cell cycle IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in cell division IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in positive regulation of G2/M transition of mitotic cell cycle IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in positive regulation of G2/MI transition of meiotic cell cycle IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in positive regulation of cell cycle G2/M phase transition IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in protein dephosphorylation IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    M-phase inducer phosphatase
    NP_496197.2
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003280.10 Reference assembly

      Range
      10188258..10189469 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_063796.5 → NP_496197.2  M-phase inducer phosphatase [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_496197.2

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q21762
      Conserved Domains (1) summary
      cd01530
      Location:58 → 176
      Cdc25; Cdc25 phosphatases are members of the Rhodanese Homology Domain superfamily. They activate the cell division kinases throughout the cell cycle progression. Cdc25 phosphatases dephosphorylate phosphotyrosine and phosphothreonine residues, in order to ...
    Nucleotide Protein
    Heading Accession and Version

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