pak-1 Serine/threonine-protein kinase pak-1 [Caenorhabditis elegans] - Gene

Summary

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Official Symbol: pak-1
Official Full Name: Serine/threonine-protein kinase pak-1
Primary source: WormBase:WBGene00003911
Locus tag: CELE_C09B8.7
See related: AllianceGenome:WB:WBGene00003911
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Caenorhabditis elegans (strain: Bristol N2)
Lineage: Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary: Enables GTP binding activity and protein kinase activity. Involved in several processes, including gonad morphogenesis; hemidesmosome assembly; and inductive cell migration. Located in several cellular components, including axon; hemidesmosome; and neuronal cell body. Is expressed in several structures, including P5.p hermaphrodite; P6.p hermaphrodite; gonad; hypodermis; and neurons. Human ortholog(s) of this gene implicated in breast cancer; ductal carcinoma in situ; non-syndromic X-linked intellectual disability 30; renal cell carcinoma; and schizophrenia. Orthologous to human PAK1 (p21 (RAC1) activated kinase 1); PAK2 (p21 (RAC1) activated kinase 2); and PAK3 (p21 (RAC1) activated kinase 3). [provided by Alliance of Genome Resources, Nov 2024]
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Genomic context

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See pak-1 in Genome Data Viewer

Location:: chromosome: X

Exon count:: 11

Sequence:: Chromosome: X; NC_003284.9 (6044308..6048608, complement)

Chromosome X - NC_003284.9 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_003284.9

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Probiotic microbes: Are their anti-melanogenicity and longevity promoting activities closely linked through the major ""pathogenic"" kinase PAK1?
Title: Probiotic microbes: Are their anti-melanogenicity and longevity promoting activities closely linked through the major "pathogenic" kinase PAK1?
FOXO-Pak1 pathway was recently shown to regulate mammalian neuronal polarity, our findings indicate that the roles of FOXO and Pak1 in neuronal migration are most likely conserved from C. elegans to higher organisms.
Title: Nonautonomous regulation of neuronal migration by insulin signaling, DAF-16/FOXO, and PAK-1.
PAK1 promotes reproduction, whereas it inactivates HSP16.2 gene and shortens lifespan.
Title: PAK1-deficiency/down-regulation reduces brood size, activates HSP16.2 gene and extends lifespan in Caenorhabditis elegans.
Pak-1 interacts with Wnt signaling to regulate tissue polarity and gene expression.
Title: p21-activated kinase interacts with Wnt signaling to regulate tissue polarity and gene expression.
Data show that combined loss of ROCK and PAK, or ROCK and MRCK, completely prevented embryonic elongation, but a constitutively active form of MLC-4 could only rescue a lack of MRCK.
Title: Myosin II regulation during C. elegans embryonic elongation: LET-502/ROCK, MRCK-1 and PAK-1, three kinases with different roles.
only PAK-1 functions in the GIT/PIX/PAK pathway independently of RAC/CDC42 GTPases.
Title: A RAC/CDC-42-independent GIT/PIX/PAK signaling pathway mediates cell migration in C. elegans.

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Pathways from PubChem

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

C09B8.7 (e-PCR)
- UniSTS:306121

Homology

Orthologs from OrthoDB

Gene Ontology Provided by WormBase

Function	Evidence Code	Pubs
enables ATP binding	IEA Inferred from Electronic Annotation more info
enables GTP binding	IDA Inferred from Direct Assay more info	PubMed
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein kinase activity	IDA Inferred from Direct Assay more info	PubMed
enables protein kinase activity	IEA Inferred from Electronic Annotation more info
enables protein serine kinase activity	IEA Inferred from Electronic Annotation more info
enables protein serine/threonine kinase activity	IBA Inferred from Biological aspect of Ancestor more info
enables protein serine/threonine kinase activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in cell migration	IBA Inferred from Biological aspect of Ancestor more info
involved_in cell migration	IGI Inferred from Genetic Interaction more info	PubMed
involved_in cellular response to starvation	IBA Inferred from Biological aspect of Ancestor more info
involved_in embryonic body morphogenesis	IGI Inferred from Genetic Interaction more info	PubMed
involved_in embryonic morphogenesis	IGI Inferred from Genetic Interaction more info	PubMed
involved_in gonad morphogenesis	IGI Inferred from Genetic Interaction more info	PubMed
involved_in gonad morphogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in hemidesmosome assembly	IGI Inferred from Genetic Interaction more info	PubMed
involved_in inductive cell migration	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in intracellular signal transduction	IBA Inferred from Biological aspect of Ancestor more info
involved_in motor neuron axon guidance	IGI Inferred from Genetic Interaction more info	PubMed
involved_in nematode larval development	IGI Inferred from Genetic Interaction more info	PubMed
involved_in nematode larval development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in nervous system development	IEA Inferred from Electronic Annotation more info
involved_in protein phosphorylation	IEA Inferred from Electronic Annotation more info
involved_in regulation of MAPK cascade	IBA Inferred from Biological aspect of Ancestor more info
involved_in regulation of axonogenesis	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
located_in axon	IDA Inferred from Direct Assay more info	PubMed
located_in axon	IEA Inferred from Electronic Annotation more info
located_in cell projection	IEA Inferred from Electronic Annotation more info
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in cytoplasm	IEA Inferred from Electronic Annotation more info
located_in cytosol	IDA Inferred from Direct Assay more info	PubMed
located_in hemidesmosome	IDA Inferred from Direct Assay more info	PubMed
located_in membrane	IDA Inferred from Direct Assay more info	PubMed
located_in neuronal cell body	IDA Inferred from Direct Assay more info	PubMed
located_in perikaryon	IEA Inferred from Electronic Annotation more info
located_in plasma membrane	IDA Inferred from Direct Assay more info	PubMed
located_in plasma membrane	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: Serine/threonine-protein kinase pak-1

NP_001024377.1

Confirmed by transcript evidence

NP_001024378.1

Confirmed by transcript evidence

NP_001024379.1

Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_003284.9 Reference assembly

Range

6044308..6048608 complement

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_001029207.4 → NP_001024378.1 Serine/threonine-protein kinase pak-1 [Caenorhabditis elegans]

See identical proteins and their annotated locations for NP_001024378.1

Status: REVIEWED

UniProtKB/Swiss-Prot

Q17850

Conserved Domains (3) summary

smart00220
Location:292 → 543

S_TKc; Serine/Threonine protein kinases, catalytic domain

pfam00786
Location:66 → 121

PBD; P21-Rho-binding domain

cl21453
Location:284 → 544

PKc_like; Protein Kinases, catalytic domain
NM_001029206.3 → NP_001024377.1 Serine/threonine-protein kinase pak-1 [Caenorhabditis elegans]

See identical proteins and their annotated locations for NP_001024377.1

Status: REVIEWED

UniProtKB/Swiss-Prot

Q17850, Q22041, Q86GT8, Q86GT9, Q86GU0, Q94133

Conserved Domains (3) summary

smart00220
Location:295 → 546

S_TKc; Serine/Threonine protein kinases, catalytic domain

pfam00786
Location:66 → 121

PBD; P21-Rho-binding domain

cl21453
Location:287 → 547

PKc_like; Protein Kinases, catalytic domain
NM_001029208.5 → NP_001024379.1 Serine/threonine-protein kinase pak-1 [Caenorhabditis elegans]

See identical proteins and their annotated locations for NP_001024379.1

Status: REVIEWED

UniProtKB/Swiss-Prot

Q17850

Conserved Domains (3) summary

smart00220
Location:246 → 497

S_TKc; Serine/Threonine protein kinases, catalytic domain

cd06647
Location:238 → 498

STKc_PAK_I; Catalytic domain of the Serine/Threonine Kinase, Group I p21-activated kinase

pfam00786
Location:20 → 75

PBD; P21-Rho-binding domain