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    gpa-1 Guanine nucleotide-binding protein alpha-1 subunit [ Caenorhabditis elegans ]

    Gene ID: 179546, updated on 9-Dec-2024

    Summary

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    Official Symbol
    gpa-1
    Official Full Name
    Guanine nucleotide-binding protein alpha-1 subunit
    Primary source
    WormBase:WBGene00001663
    Locus tag
    CELE_T19C4.6
    See related
    AllianceGenome:WB:WBGene00001663
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Predicted to enable G protein-coupled receptor binding activity; G-protein beta/gamma-subunit complex binding activity; and GTPase activity. Predicted to be involved in adenylate cyclase-modulating G protein-coupled receptor signaling pathway. Predicted to be part of heterotrimeric G-protein complex. Predicted to be active in cytoplasm. Is expressed in several structures, including SPD; chemosensory neurons; head mesodermal cell; pharyngeal neurons; and postcloacal sensillum. [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See gpa-1 in Genome Data Viewer
    Location:
    chromosome: V
    Exon count:
    8
    Sequence:
    Chromosome: V; NC_003283.11 (11174433..11177677, complement)

    Chromosome V - NC_003283.11Genomic Context describing neighboring genes Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene GLOBIN domain-containing protein Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene tRNA-Leu Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene CaeNaCin (Caenorhabditis bacteriocin)

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003283.11

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Tc7, a Tc1-hitch hiking transposon in Caenorhabditis elegans. Rezsohazy R, et al. Nucleic Acids Res, 1997 Oct 15. PMID 9321656, Free PMC Article
    2. Functional constraint and divergence in the G protein family in Caenorhabditis elegans and Caenorhabditis briggsae. Jovelin R, et al. Mol Genet Genomics, 2005 Jun. PMID 15856303
    3. Serotonin and Go modulate functional states of neurons and muscles controlling C. elegans egg-laying behavior. Shyn SI, et al. Curr Biol, 2003 Oct 28. PMID 14588249
    4. Reverse genetics of Caenorhabditis elegans. Plasterk RH. Bioessays, 1992 Sep. PMID 1365920
    5. Structural determinants underlying the temperature-sensitive nature of a Galpha mutant in asymmetric cell division of Caenorhabditis elegans. Johnston CA, et al. J Biol Chem, 2008 Aug 1. PMID 18519563, Free PMC Article

    See all (36) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. analysis of structural determinants underlying the temperature-sensitive nature of a Galpha mutant
      Title: Structural determinants underlying the temperature-sensitive nature of a Galpha mutant in asymmetric cell division of Caenorhabditis elegans.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables G protein-coupled receptor binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables G-protein beta/gamma-subunit complex binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables G-protein beta/gamma-subunit complex binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables GTP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables GTPase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables GTPase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables guanyl nucleotide binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in G protein-coupled receptor signaling pathway IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in adenylate cyclase-modulating G protein-coupled receptor signaling pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in signal transduction IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of heterotrimeric G-protein complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    Guanine nucleotide-binding protein alpha-1 subunit
    NP_001123018.1
    • Confirmed by transcript evidence
    NP_505840.1
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003283.11 Reference assembly

      Range
      11174433..11177677 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_073439.3 → NP_505840.1  Guanine nucleotide-binding protein alpha-1 subunit [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_505840.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      P28051, Q22567
      Conserved Domains (2) summary
      cd00066
      Location:34 → 348
      G-alpha; Alpha subunit of G proteins (guanine nucleotide binding)
      smart00275
      Location:13 → 355
      G_alpha; G protein alpha subunit

    2. NM_001129546.4 → NP_001123018.1  Guanine nucleotide-binding protein alpha-1 subunit [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_001123018.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      B2D6M7
      Conserved Domains (2) summary
      cd00066
      Location:1 → 296
      G-alpha; Alpha subunit of G proteins (guanine nucleotide binding)
      pfam00503
      Location:1 → 294
      G-alpha; G-protein alpha subunit
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P28051.2

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