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    tbcb-1 Tubulin-specific chaperone B [ Caenorhabditis elegans ]

    Gene ID: 186176, updated on 9-Dec-2024

    Summary

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    Official Symbol
    tbcb-1
    Official Full Name
    Tubulin-specific chaperone B
    Primary source
    WormBase:WBGene00009987
    Locus tag
    CELE_F53F4.3
    See related
    AllianceGenome:WB:WBGene00009987
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Predicted to be located in cytoplasm and microtubule. Orthologous to human TBCB (tubulin folding cofactor B). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See tbcb-1 in Genome Data Viewer
    Location:
    chromosome: V
    Exon count:
    4
    Sequence:
    Chromosome: V; NC_003283.11 (13592124..13593183)

    Chromosome V - NC_003283.11Genomic Context describing neighboring genes Neighboring gene Uncharacterized protein Neighboring gene ncRNA Neighboring gene DUF4342 domain-containing protein Neighboring gene DUF19 domain-containing protein;Secreted protein Neighboring gene MARVEL domain-containing protein Neighboring gene ncRNA

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003283.11

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Crystal structure of the cytoskeleton-associated protein glycine-rich (CAP-Gly) domain. Li S, et al. J Biol Chem, 2002 Dec 13. PMID 12221106
    2. Solution structure of a ubiquitin-like domain from tubulin-binding cofactor B. Lytle BL, et al. J Biol Chem, 2004 Nov 5. PMID 15364906
    3. Actin-dependent cytoplasmic streaming in C. elegans oogenesis. Wolke U, et al. Development, 2007 Jun. PMID 17507392
    4. In situ imaging in C. elegans reveals developmental regulation of microtubule dynamics. Lacroix B, et al. Dev Cell, 2014 Apr 28. PMID 24780738, Free PMC Article
    5. Depletion of endogenously biotinylated carboxylases enhances the sensitivity of TurboID-mediated proximity labeling in Caenorhabditis elegans. Artan M, et al. J Biol Chem, 2022 Sep. PMID 35933017, Free PMC Article

    See all (10) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. determination of structure of glycine-rick domain
      Title: Crystal structure of the cytoskeleton-associated protein glycine-rich (CAP-Gly) domain.
    2. tubulin-binding cofactor B ubiquitin-like domain structure
      Title: Solution structure of a ubiquitin-like domain from tubulin-binding cofactor B.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by WormBase

    Component Evidence Code Pubs
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytoskeleton IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in microtubule IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    Tubulin-specific chaperone B
    NP_506367.1
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003283.11 Reference assembly

      Range
      13592124..13593183
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_073966.4 → NP_506367.1  Tubulin-specific chaperone B [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_506367.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q20728
      Conserved Domains (2) summary
      cd01789
      Location:4 → 87
      Alp11_N; Ubiquitin-like domain of Alp11 tubulin-folding cofactor B
      pfam01302
      Location:149 → 216
      CAP_GLY; CAP-Gly domain
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q20728.1

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