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    pdi-3 Protein disulfide-isomerase [ Caenorhabditis elegans ]

    Gene ID: 172433, updated on 2-Nov-2024

    Summary

    Official Symbol
    pdi-3
    Official Full Name
    Protein disulfide-isomerase
    Primary source
    WormBase:WBGene00003964
    Locus tag
    CELE_H06O01.1
    See related
    AllianceGenome:WB:WBGene00003964
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Enables protein disulfide isomerase activity and protein-glutamine gamma-glutamyltransferase activity. Involved in several processes, including collagen and cuticulin-based cuticle development; egg-laying behavior; and male anatomical structure morphogenesis. Predicted to be located in endoplasmic reticulum lumen. Predicted to be active in endoplasmic reticulum. Is expressed in hypodermis and intestine. Human ortholog(s) of this gene implicated in autoimmune hepatitis. Orthologous to human PDIA3 (protein disulfide isomerase family A member 3). [provided by Alliance of Genome Resources, Nov 2024]
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    Genomic context

    See pdi-3 in Genome Data Viewer
    Location:
    chromosome: I
    Exon count:
    8
    Sequence:
    Chromosome: I; NC_003279.8 (7015912..7020797, complement)

    Chromosome I - NC_003279.8Genomic Context describing neighboring genes Neighboring gene Protein ctg-1 Neighboring gene DNA helicase Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene Ubiquilin

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables isomerase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables protein disulfide isomerase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables protein disulfide isomerase activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables protein disulfide isomerase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables protein-glutamine gamma-glutamyltransferase activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    Process Evidence Code Pubs
    involved_in body morphogenesis IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    involved_in collagen and cuticulin-based cuticle development IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    involved_in collagen and cuticulin-based cuticle development IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in egg-laying behavior IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    involved_in nematode male tail mating organ morphogenesis IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    involved_in nematode male tail tip morphogenesis IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    involved_in positive regulation of embryonic development IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    involved_in protein folding IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in regulation of cell shape IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    involved_in response to endoplasmic reticulum stress IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    Component Evidence Code Pubs
    is_active_in endoplasmic reticulum IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in endoplasmic reticulum IEA
    Inferred from Electronic Annotation
    more info
     
    located_in endoplasmic reticulum lumen IEA
    Inferred from Electronic Annotation
    more info
     

    General protein information

    Preferred Names
    Protein disulfide-isomerase
    NP_491995.1
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003279.8 Reference assembly

      Range
      7015912..7020797 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_059594.9NP_491995.1  Protein disulfide-isomerase [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_491995.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      G5ED07
      Conserved Domains (5) summary
      cd02995
      Location:364465
      PDI_a_PDI_a'_C; PDIa family, C-terminal TRX domain (a') subfamily; composed of the C-terminal redox active a' domains of PDI, ERp72, ERp57 (or ERp60) and EFP1. PDI, ERp72 and ERp57 are endoplasmic reticulum (ER)-resident eukaryotic proteins involved in oxidative protein ...
      cd03069
      Location:130232
      PDI_b_ERp57; PDIb family, ERp57 subfamily, first redox inactive TRX-like domain b; ERp57 (or ERp60) exhibits both disulfide oxidase and reductase functions like PDI, by catalyzing the formation of disulfide bonds of newly synthesized polypeptides in the ER and acting ...
      cd03073
      Location:236344
      PDI_b'_ERp72_ERp57; PDIb' family, ERp72 and ERp57 subfamily, second redox inactive TRX-like domain b'; ERp72 and ER57 are involved in oxidative protein folding in the ER, like PDI. They exhibit both disulfide oxidase and reductase functions, by catalyzing the formation of ...
      TIGR01130
      Location:21477
      ER_PDI_fam; protein disulfide isomerase, eukaryotic
      cl00388
      Location:26127
      Thioredoxin_like; Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold