pax-3 Paired box protein 3 homolog [Caenorhabditis elegans] - Gene

Summary

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Official Symbol: pax-3
Official Full Name: Paired box protein 3 homolog
Primary source: WormBase:WBGene00003939
Locus tag: CELE_F27E5.2
See related: AllianceGenome:WB:WBGene00003939
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Caenorhabditis elegans (strain: Bristol N2)
Lineage: Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary: Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Involved in epidermal cell fate specification; gonad morphogenesis; and hemidesmosome assembly. Located in nucleus. Is expressed in several structures, including AB lineage cell; E lineage cell; P9/10L; hypodermal cell; and tail. Human ortholog(s) of this gene implicated in alveolar rhabdomyosarcoma and congenital myopathy 19. Orthologous to human PAX7 (paired box 7). [provided by Alliance of Genome Resources, Dec 2024]
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Genomic context

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See pax-3 in Genome Data Viewer

Location:: chromosome: II

Exon count:: 7

Sequence:: Chromosome: II; NC_003280.10 (10146570..10152865)

Chromosome II - NC_003280.10 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_003280.10

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Data indicate taht Paired-box protein pax-3 is the first gene required for specification of the ventral hypodermal fate.
Title: The Paired-box protein PAX-3 regulates the choice between lateral and ventral epidermal cell fates in C. elegans.

Submit: New GeneRIF Correction

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

F27E5.2 (e-PCR)
- UniSTS:322087

Homology

Orthologs from OrthoDB

Gene Ontology Provided by WormBase

Function	Evidence Code	Pubs
enables DNA binding	IEA Inferred from Electronic Annotation more info
enables DNA-binding transcription factor activity, RNA polymerase II-specific	IBA Inferred from Biological aspect of Ancestor more info
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding	IBA Inferred from Biological aspect of Ancestor more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
involved_in epidermal cell fate specification	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in gonad morphogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in hemidesmosome assembly	IGI Inferred from Genetic Interaction more info	PubMed
involved_in nervous system development	IBA Inferred from Biological aspect of Ancestor more info
involved_in regulation of DNA-templated transcription	IEA Inferred from Electronic Annotation more info
involved_in regulation of transcription by RNA polymerase II	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
located_in intracellular organelle	IEA Inferred from Electronic Annotation more info
located_in nucleus	IDA Inferred from Direct Assay more info	PubMed
located_in nucleus	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: Paired box protein 3 homolog

NP_496189.2

Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_003280.10 Reference assembly

Range

10146570..10152865

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_063788.3 → NP_496189.2 Paired box protein 3 homolog [Caenorhabditis elegans]

See identical proteins and their annotated locations for NP_496189.2

Status: REVIEWED

UniProtKB/Swiss-Prot

G5ED66

Conserved Domains (2) summary

smart00389
Location:187 → 243

HOX; Homeodomain

cd00131
Location:13 → 141

PAX; Paired Box domain