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    fkb-6 peptidylprolyl isomerase [ Caenorhabditis elegans ]

    Gene ID: 180371, updated on 9-Dec-2024

    Summary

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    Official Symbol
    fkb-6
    Official Full Name
    peptidylprolyl isomerase
    Primary source
    WormBase:WBGene00001431
    Locus tag
    CELE_F31D4.3
    See related
    AllianceGenome:WB:WBGene00001431
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Enables Hsp90 protein binding activity and peptidyl-prolyl cis-trans isomerase activity. Predicted to be involved in chaperone-mediated protein folding. Predicted to be active in cytoplasm. Is expressed in several structures, including anal depressor muscle; excretory cell; hypodermis; nervous system; and reproductive system. Human ortholog(s) of this gene implicated in alcohol dependence; heroin dependence; and major depressive disorder. Orthologous to human FKBP4 (FKBP prolyl isomerase 4) and FKBP5 (FKBP prolyl isomerase 5). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See fkb-6 in Genome Data Viewer
    Location:
    chromosome: V
    Exon count:
    3
    Sequence:
    Chromosome: V; NC_003283.11 (20846158..20847727)

    Chromosome V - NC_003283.11Genomic Context describing neighboring genes Neighboring gene Small ribosomal subunit protein uS12m Neighboring gene Ribosomal RNA-processing protein 42 Neighboring gene Sugar phosphate phosphatase Neighboring gene C-type lectin domain-containing protein Neighboring gene NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 1 Neighboring gene Pleckstrin homology domain-containing family D member 1 Neighboring gene Peptidase S1 domain-containing protein

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003283.11

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Regulating chromosomal movement by the cochaperone FKB-6 ensures timely pairing and synapsis. Alleva B, et al. J Cell Biol, 2017 Feb. PMID 28077446, Free PMC Article
    2. Cloning, expression and characterisation of FKB-6, the sole large TPR-containing immunophilin from C. elegans. Richardson JM, et al. Biochem Biophys Res Commun, 2007 Aug 31. PMID 17610845
    3. Glucocorticoid receptor complexes form cooperatively with the Hsp90 co-chaperones Pp5 and FKBPs. Kaziales A, et al. Sci Rep, 2020 Jul 1. PMID 32612187, Free PMC Article
    4. Sequence diversification of the FK506-binding proteins in several different genomes. Galat A. Eur J Biochem, 2000 Aug. PMID 10931176
    5. The C. elegans dosage compensation complex propagates dynamically and independently of X chromosome sequence. Ercan S, et al. Curr Biol, 2009 Nov 17. PMID 19853451, Free PMC Article

    See all (17) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables Hsp90 protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables isomerase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables peptidyl-prolyl cis-trans isomerase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables peptidyl-prolyl cis-trans isomerase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables peptidyl-prolyl cis-trans isomerase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    peptidylprolyl isomerase
    NP_508026.1
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003283.11 Reference assembly

      Range
      20846158..20847727
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_075625.7 → NP_508026.1  peptidylprolyl isomerase [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_508026.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      O45418
      Conserved Domains (4) summary
      sd00006
      Location:254 → 282
      TPR; TPR repeat [structural motif]
      pfam00254
      Location:26 → 117
      FKBP_C; FKBP-type peptidyl-prolyl cis-trans isomerase
      pfam00515
      Location:337 → 370
      TPR_1; Tetratricopeptide repeat
      pfam13414
      Location:305 → 368
      TPR_11; TPR repeat
    Nucleotide Protein
    Heading Accession and Version

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