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    glrx-10 Glutaredoxin-1 [ Caenorhabditis elegans ]

    Gene ID: 171685, updated on 9-Dec-2024

    Summary

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    Official Symbol
    glrx-10
    Official Full Name
    Glutaredoxin-1
    Primary source
    WormBase:WBGene00021331
    Locus tag
    CELE_Y34D9A.6
    See related
    AllianceGenome:WB:WBGene00021331
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Predicted to enable glutathione disulfide oxidoreductase activity. Is expressed in body wall musculature; intestine; pharynx; and reproductive system. Used to study Parkinson's disease. Orthologous to human GLRX (glutaredoxin). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See glrx-10 in Genome Data Viewer
    Location:
    chromosome: I
    Exon count:
    2
    Sequence:
    Chromosome: I; NC_003279.8 (1049596..1050727)

    Chromosome I - NC_003279.8Genomic Context describing neighboring genes Neighboring gene Protein regulator of cytokinesis 1 Neighboring gene MIF4G domain-containing protein;THO complex subunit 2;TPR_REGION domain-containing protein;Uncharacterized protein Neighboring gene PSP domain-containing protein;PSP proline-rich domain-containing protein Neighboring gene Conserved plasma membrane protein;Low-density lipoprotein receptor domain class A;Transmembrane protein Neighboring gene vesicle-fusing ATPase Neighboring gene G-protein coupled receptors family 1 profile domain-containing protein Neighboring gene Guanine nucleotide-binding protein G(s) subunit alpha

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003279.8

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Glutaredoxin deficiency exacerbates neurodegeneration in C. elegans models of Parkinson's disease. Johnson WM, et al. Hum Mol Genet, 2015 Mar 1. PMID 25355420, Free PMC Article
    2. Redox properties and evolution of human glutaredoxins. Sagemark J, et al. Proteins, 2007 Sep 1. PMID 17546662
    3. The Redox System in C. elegans, a Phylogenetic Approach. Johnston AD, et al. J Toxicol, 2012. PMID 22899914, Free PMC Article
    4. Antagonistic fungal enterotoxins intersect at multiple levels with host innate immune defences. Zhang X, et al. PLoS Genet, 2021 Jun. PMID 34166401, Free PMC Article
    5. Characterization of the intracellular neurexin interactome by in vivo proximity ligation suggests its involvement in presynaptic actin assembly. Schaan Profes M, et al. PLoS Biol, 2024 Jan. PMID 38252619, Free PMC Article

    See all (12) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Re-expression of GLRX-10 selectively in dopaminergic neurons attenuates mutant LRRK2-mediated phenotype.
      Title: Glutaredoxin deficiency exacerbates neurodegeneration in C. elegans models of Parkinson's disease.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables glutathione disulfide oxidoreductase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    Glutaredoxin-1
    NP_490812.1
    • Partially confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003279.8 Reference assembly

      Range
      1049596..1050727
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_058411.6 → NP_490812.1  Glutaredoxin-1 [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_490812.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q9N456
      Conserved Domains (1) summary
      TIGR02180
      Location:15 → 99
      GRX_euk; Glutaredoxin
    Nucleotide Protein
    Heading Accession and Version

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