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    fpn-1.1 Solute carrier family 40 member [ Caenorhabditis elegans ]

    Gene ID: 171773, updated on 9-Dec-2024

    Summary

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    Official Symbol
    fpn-1.1
    Official Full Name
    Solute carrier family 40 member
    Primary source
    WormBase:WBGene00021354
    Locus tag
    CELE_Y37E3.16
    See related
    AllianceGenome:WB:WBGene00021354
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Predicted to enable iron ion transmembrane transporter activity. Predicted to be involved in iron ion transmembrane transport. Predicted to be located in membrane. Used to study Parkinson's disease. Human ortholog(s) of this gene implicated in hemochromatosis type 4. Orthologous to human SLC40A1 (solute carrier family 40 member 1). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See fpn-1.1 in Genome Data Viewer
    Location:
    chromosome: I
    Exon count:
    9
    Sequence:
    Chromosome: I; NC_003279.8 (2113656..2118530, complement)

    Chromosome I - NC_003279.8Genomic Context describing neighboring genes Neighboring gene IstB_IS21 domain-containing protein;Secreted protein;ethanolamine-phosphate cytidylyltransferase Neighboring gene Ig-like domain-containing protein Neighboring gene Nuclear pore protein Neighboring gene Uncharacterized protein Neighboring gene Dimethylglycine dehydrogenase, mitochondrial Neighboring gene Rx N-terminal domain-containing protein Neighboring gene ncRNA

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003279.8

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Non-mutagenic Suppression of Enterocyte Ferroportin 1 by Chemical Ribosomal Inactivation via p38 Mitogen-activated Protein Kinase (MAPK)-mediated Regulation: EVIDENCE FOR ENVIRONMENTAL HEMOCHROMATOSIS. Oh CK, et al. J Biol Chem, 2016 Sep 16. PMID 27445333, Free PMC Article
    2. Loss of pdr-1/parkin influences Mn homeostasis through altered ferroportin expression in C. elegans. Chakraborty S, et al. Metallomics, 2015 May. PMID 25769119, Free PMC Article
    3. Screening for cold tolerance genes in C. elegans, whose expressions are affected by anticancer drugs camptothecin and leptomycin B. Okahata M, et al. Sci Rep, 2024 Mar 5. PMID 38443452, Free PMC Article
    4. Amino acid and protein specificity of protein fatty acylation in C. elegans. Zhang B, et al. Proc Natl Acad Sci U S A, 2024 Jan 30. PMID 38252833, Free PMC Article
    5. OrthoList: a compendium of C. elegans genes with human orthologs. Shaye DD, et al. PLoS One, 2011. PMID 21647448, Free PMC Article

    See all (7) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. ribosomal inactivation-induced iron accumulation in Caenorhabditis elegans as a simplified in vivo model for gut nutrition uptake was dependent on SEK-1, a p38 kinase activator, leading to suppression of FPN-1.1 expression and iron accumulation.
      Title: Non-mutagenic Suppression of Enterocyte Ferroportin 1 by Chemical Ribosomal Inactivation via p38 Mitogen-activated Protein Kinase (MAPK)-mediated Regulation: EVIDENCE FOR ENVIRONMENTAL HEMOCHROMATOSIS.
    2. While no change in mRNA expression of the major Mn importer proteins (smf-1-3) was found in pdr-1 mutants, significant downregulation in mRNA levels of the putative Mn exporter ferroportin (fpn-1.1) was observed.
      Title: Loss of pdr-1/parkin influences Mn homeostasis through altered ferroportin expression in C. elegans.
    Submit: New GeneRIF Correction

    General gene information

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    Homology

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables iron ion transmembrane transporter activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in iron ion transmembrane transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in monoatomic ion transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in transmembrane transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    Solute carrier family 40 member
    NP_001032985.1
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003279.8 Reference assembly

      Range
      2113656..2118530 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001037896.4 → NP_001032985.1  Solute carrier family 40 member [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_001032985.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q8IA95
      Conserved Domains (1) summary
      pfam06963
      Location:5 → 448
      FPN1; Ferroportin1 (FPN1)
    Nucleotide Protein
    Heading Accession and Version

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