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    har-1 Hemiasterlin resistant protein 1 [ Caenorhabditis elegans ]

    Gene ID: 175529, updated on 9-Dec-2024

    Summary

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    Official Symbol
    har-1
    Official Full Name
    Hemiasterlin resistant protein 1
    Primary source
    WormBase:WBGene00007630
    Locus tag
    CELE_C16C10.11
    See related
    AllianceGenome:WB:WBGene00007630
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Involved in mitochondrion organization. Acts upstream of with a positive effect on determination of adult lifespan. Located in mitochondrion and striated muscle dense body. Is expressed in anal depressor muscle; body wall musculature; intestine; nervous system; and pharynx. Human ortholog(s) of this gene implicated in Parkinson's disease 22; frontotemporal dementia and/or amyotrophic lateral sclerosis 2; isolated mitochondrial myopathy; and spinal muscular atrophy, Jokela type. Orthologous to several human genes including CHCHD10 (coiled-coil-helix-coiled-coil-helix domain containing 10). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See har-1 in Genome Data Viewer
    Location:
    chromosome: III
    Exon count:
    3
    Sequence:
    Chromosome: III; NC_003281.10 (4152054..4152915)

    Chromosome III - NC_003281.10Genomic Context describing neighboring genes Neighboring gene Cyclic nucleotide-binding domain-containing protein;Potassium voltage-gated channel unc-103 Neighboring gene ncRNA Neighboring gene ABC transporter ATP-binding protein/permease wht-3;ABC transporter domain-containing protein Neighboring gene Glyoxalase 1 Neighboring gene Uncharacterized protein

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003281.10

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Loss of function CHCHD10 mutations in cytoplasmic TDP-43 accumulation and synaptic integrity. Woo JA, et al. Nat Commun, 2017 Jun 6. PMID 28585542, Free PMC Article
    2. Mitochondrial dysfunction confers resistance to multiple drugs in Caenorhabditis elegans. Zubovych IO, et al. Mol Biol Cell, 2010 Mar 15. PMID 20089839, Free PMC Article
    3. The matrix peptide exporter HAF-1 signals a mitochondrial UPR by activating the transcription factor ZC376.7 in C. elegans. Haynes CM, et al. Mol Cell, 2010 Feb 26. PMID 20188671, Free PMC Article
    4. Determining the sub-cellular localization of proteins within Caenorhabditis elegans body wall muscle. Meissner B, et al. PLoS One, 2011. PMID 21611156, Free PMC Article
    5. OrthoList: a compendium of C. elegans genes with human orthologs. Shaye DD, et al. PLoS One, 2011. PMID 21647448, Free PMC Article

    See all (7) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by WormBase

    Process Evidence Code Pubs
    acts_upstream_of_positive_effect determination of adult lifespan IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in mitochondrion organization IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in mitochondrion organization IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in cytoplasm HDA PubMed 
    located_in mitochondrion HDA PubMed 
    is_active_in mitochondrion IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in mitochondrion ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in striated muscle dense body HDA PubMed 

    General protein information

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    Preferred Names
    Hemiasterlin resistant protein 1
    NP_497826.1
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003281.10 Reference assembly

      Range
      4152054..4152915
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_065425.4 → NP_497826.1  Hemiasterlin resistant protein 1 [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_497826.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q09254
      Conserved Domains (2) summary
      COG3416
      Location:7 → 90
      COG3416; Uncharacterized protein [Function unknown]
      pfam06747
      Location:119 → 152
      CHCH; CHCH domain
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q09254.1

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