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    Cnih3 cornichon family AMPA receptor auxiliary protein 3 [ Mus musculus (house mouse) ]

    Gene ID: 72978, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Cnih3provided by MGI
    Official Full Name
    cornichon family AMPA receptor auxiliary protein 3provided by MGI
    Primary source
    MGI:MGI:1920228
    See related
    Ensembl:ENSMUSG00000026514 AllianceGenome:MGI:1920228
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    CNIH-3; 2900075G08Rik
    Summary
    Predicted to enable channel regulator activity and signaling receptor binding activity. Involved in neurotransmitter receptor localization to postsynaptic specialization membrane. Is active in glutamatergic synapse. Is expressed in several structures, including alimentary system; genitourinary system; nervous system; sensory organ; and skeleton. Orthologous to human CNIH3 (cornichon family AMPA receptor auxiliary protein 3). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in frontal lobe adult (RPKM 13.2), cortex adult (RPKM 12.3) and 4 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Cnih3 in Genome Data Viewer
    Location:
    1 84.53 cM; 1 H4
    Exon count:
    6
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 1 NC_000067.7 (181178024..181288059)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 1 NC_000067.6 (181350459..181460641)

    Chromosome 1 - NC_000067.7Genomic Context describing neighboring genes Neighboring gene HAUS augmin-like complex, subunit 5 pseudogene Neighboring gene predicted gene, 39717 Neighboring gene predicted gene 16547 Neighboring gene STARR-seq mESC enhancer starr_03238 Neighboring gene coiled-coil domain containing 121, retrogene 1 Neighboring gene STARR-seq mESC enhancer starr_03239 Neighboring gene predicted gene, 32767

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Cnih3 Deletion Dysregulates Dorsal Hippocampal Transcription across the Estrous Cycle. Mulvey B, et al. eNeuro, 2023 Mar. PMID 36849260, Free PMC Article
    2. Sex Differences in the Role of CNIH3 on Spatial Memory and Synaptic Plasticity. Frye HE, et al. Biol Psychiatry, 2021 Dec 1. PMID 34548146, Free PMC Article
    3. Evidence of CNIH3 involvement in opioid dependence. Nelson EC, et al. Mol Psychiatry, 2016 May. PMID 26239289, Free PMC Article
    4. Cornichon proteins determine the subunit composition of synaptic AMPA receptors. Herring BE, et al. Neuron, 2013 Mar 20. PMID 23522044, Free PMC Article
    5. Gene expression in the developing mouse retina by EST sequencing and microarray analysis. Mu X, et al. Nucleic Acids Res, 2001 Dec 15. PMID 11812828, Free PMC Article

    See all (22) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (2) 
    • Targeted (3)  1 citation

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables channel regulator activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables signaling receptor binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within localization within membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in neurotransmitter receptor localization to postsynaptic specialization membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in neurotransmitter receptor localization to postsynaptic specialization membrane IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in regulation of AMPA receptor activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in regulation of AMPA receptor activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    acts_upstream_of_or_within regulation of membrane potential ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in synaptic transmission, glutamatergic IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within synaptic transmission, glutamatergic ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in vesicle-mediated transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    part_of AMPA glutamate receptor complex ISO
    Inferred from Sequence Orthology
    more info
    		  
    part_of AMPA glutamate receptor complex ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    is_active_in dendrite IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in dendritic shaft ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in dendritic shaft ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    is_active_in glutamatergic synapse IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in glutamatergic synapse IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    located_in postsynaptic membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in postsynaptic membrane ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    is_active_in synapse IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    protein cornichon homolog 3
    Names
    cornichon homolog 3

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001160211.2 → NP_001153683.1  protein cornichon homolog 3 isoform 2

      See identical proteins and their annotated locations for NP_001153683.1

      Status: VALIDATED

      Source sequence(s)
      AC113084, AC119235
      Consensus CDS
      CCDS48470.1
      UniProtKB/Swiss-Prot
      Q14BS0, Q6ZWS4
      Related
      ENSMUSP00000027795.8, ENSMUST00000027795.14
      Conserved Domains (1) summary
      pfam03311
      Location:7 → 151
      Cornichon; Cornichon protein

    2. NM_001160212.2 → NP_001153684.1  protein cornichon homolog 3 isoform 3

      See identical proteins and their annotated locations for NP_001153684.1

      Status: VALIDATED

      Source sequence(s)
      AC113084, AC119235
      Consensus CDS
      CCDS48471.1
      UniProtKB/TrEMBL
      G3XA11
      Related
      ENSMUSP00000124247.2, ENSMUST00000162685.2
      Conserved Domains (1) summary
      pfam03311
      Location:7 → 106
      Cornichon; Cornichon protein

    3. NM_028408.4 → NP_082684.1  protein cornichon homolog 3 isoform 1

      See identical proteins and their annotated locations for NP_082684.1

      Status: VALIDATED

      Source sequence(s)
      AC113084, AC119235
      Consensus CDS
      CCDS35810.1
      UniProtKB/TrEMBL
      Q9D6E1
      Related
      ENSMUSP00000124611.2, ENSMUST00000161880.8
      Conserved Domains (1) summary
      pfam03311
      Location:7 → 170
      Cornichon; Cornichon protein

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000067.7 Reference GRCm39 C57BL/6J

      Range
      181178024..181288059
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_030243142.1 → XP_030099002.1  protein cornichon homolog 3 isoform X1

      UniProtKB/TrEMBL
      A0A1B0GSP1
      Related
      ENSMUSP00000148015.2, ENSMUST00000209607.2
      Conserved Domains (1) summary
      pfam03311
      Location:8 → 178
      Cornichon; Cornichon protein

    2. XM_006496989.5 → XP_006497052.1  protein cornichon homolog 3 isoform X2

      Conserved Domains (1) summary
      pfam03311
      Location:8 → 125
      Cornichon; Cornichon protein
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q6ZWS4.1 GenPept UniProtKB/Swiss-Prot:Q6ZWS4

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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