irg-7 Protein irg-7 [Caenorhabditis elegans] - Gene

Summary

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Official Symbol: irg-7
Official Full Name: Protein irg-7
Primary source: WormBase:WBGene00018237
Locus tag: CELE_F40F4.6
See related: AllianceGenome:WB:WBGene00018237
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Caenorhabditis elegans (strain: Bristol N2)
Lineage: Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary: Predicted to enable carbohydrate binding activity. Predicted to be involved in innate immune response. Predicted to be located in extracellular region. Is expressed in intestine. [provided by Alliance of Genome Resources, Dec 2024]
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Genomic context

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See irg-7 in Genome Data Viewer

Location:: chromosome: X

Exon count:: 23

Sequence:: Chromosome: X; NC_003284.9 (3235754..3243636, complement)

Chromosome X - NC_003284.9 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_003284.9

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

irg-7 activation by itself sensitizes the animals' innate immune response and extends the lifespan of animals exposed to live bacteria. This lifespan-extending pathogen resistance relies on the somatic gonad as well as on many genes previously associated with the reproductive longevity pathway.
Title: Innate immunity mediated longevity and longevity induced by germ cell removal converge on the C-type lectin domain protein IRG-7.

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

F40F4.6 (e-PCR)
- UniSTS:310226

Homology

Orthologs from OrthoDB

Gene Ontology Provided by WormBase

Function	Evidence Code	Pubs
enables carbohydrate binding	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in innate immune response	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in extracellular region	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: Protein irg-7

NP_001362066.1

Confirmed by transcript evidence

NP_508552.2

Partially confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_003284.9 Reference assembly

Range

3235754..3243636 complement

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_076151.7 → NP_508552.2 Protein irg-7 [Caenorhabditis elegans]

See identical proteins and their annotated locations for NP_508552.2

Status: REVIEWED

UniProtKB/Swiss-Prot

A0A131MBU3

Conserved Domains (4) summary

smart00034
Location:1178 → 1310

CLECT; C-type lectin (CTL) or carbohydrate-recognition domain (CRD)

smart00604
Location:178 → 316

MD; MD domain

pfam00092
Location:2013 → 2191

VWA; von Willebrand factor type A domain

pfam07974
Location:1471 → 1500

EGF_2; EGF-like domain
NM_001374988.3 → NP_001362066.1 Protein irg-7 [Caenorhabditis elegans]

Status: REVIEWED

UniProtKB/Swiss-Prot

A0A131MBU3, Q20219

Conserved Domains (3) summary

smart00034
Location:1181 → 1313

CLECT; C-type lectin (CTL) or carbohydrate-recognition domain (CRD)

smart00604
Location:181 → 319

MD; MD domain

pfam00092
Location:2016 → 2194

VWA; von Willebrand factor type A domain