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    act-3 Actin-3 [ Caenorhabditis elegans ]

    Gene ID: 179533, updated on 9-Dec-2024

    Summary

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    Official Symbol
    act-3
    Official Full Name
    Actin-3
    Primary source
    WormBase:WBGene00000065
    Locus tag
    CELE_T04C12.4
    See related
    AllianceGenome:WB:WBGene00000065
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Predicted to be involved in mitotic cytokinesis. Predicted to be active in actin cytoskeleton. Is expressed in body wall musculature; gonad; head; nervous system; and pharynx. Human ortholog(s) of this gene implicated in Baraitser-Winter syndrome 1; Baraitser-Winter syndrome 2; autosomal dominant nonsyndromic deafness 20; and thrombocytopenia. Orthologous to several human genes including ACTB (actin beta). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See act-3 in Genome Data Viewer
    Location:
    chromosome: V
    Exon count:
    3
    Sequence:
    Chromosome: V; NC_003283.11 (11071690..11073264, complement)

    Chromosome V - NC_003283.11Genomic Context describing neighboring genes Neighboring gene Secreted protein Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003283.11

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Efficiency of Protein Renewal Is Limited by Feed Intake and Not by Protein Lifetime in Aging Caenorhabditis elegans. Khanijou JK, et al. J Proteome Res, 2022 Nov 4. PMID 36181456
    2. Molecular characterization of the histone gene family of Caenorhabditis elegans. Roberts SB, et al. J Mol Biol, 1987 Jul 5. PMID 3656446
    3. DNA rearrangements of the actin gene cluster in Caenorhabditis elegans accompany reversion of three muscle mutants. Landel CP, et al. J Mol Biol, 1984 Dec 15. PMID 6098683
    4. Early C. elegans embryos are transcriptionally active. Schauer IE, et al. Development, 1990 Dec. PMID 2100265
    5. Gene expression in the Caenorhabditis elegans dauer larva: developmental regulation of Hsp90 and other genes. Dalley BK, et al. Dev Biol, 1992 May. PMID 1577199

    See all (54) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by WormBase

    Process Evidence Code Pubs
    involved_in mitotic cytokinesis IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in actin cytoskeleton IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    Actin-3
    NP_001366892.1
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003283.11 Reference assembly

      Range
      11071690..11073264 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001380754.2 → NP_001366892.1  Actin-3 [Caenorhabditis elegans]

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      P0DM41, P0DM42, P10983, P10985
      Conserved Domains (1) summary
      PTZ00281
      Location:1 → 376
      PTZ00281; actin; Provisional
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P0DM41.1
    P0DM42.1

    Gene LinkOut

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    Chemical Information
    Molecular Biology Databases
    Research Materials