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    rskn-1 Putative ribosomal protein S6 kinase alpha-1;Ribosomal protein S6 kinase [ Caenorhabditis elegans ]

    Gene ID: 172647, updated on 9-Dec-2024

    Summary

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    Official Symbol
    rskn-1
    Official Full Name
    Putative ribosomal protein S6 kinase alpha-1;Ribosomal protein S6 kinase
    Primary source
    WormBase:WBGene00011352
    Locus tag
    CELE_T01H8.1
    See related
    AllianceGenome:WB:WBGene00011352
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Predicted to enable ribosomal protein S6 kinase activity. Predicted to be involved in TORC1 signaling. Predicted to be active in cytoplasm and nucleoplasm. Human ortholog(s) of this gene implicated in Coffin-Lowry syndrome; intellectual disability; and non-syndromic X-linked intellectual disability 19. Orthologous to several human genes including RPS6KA1 (ribosomal protein S6 kinase A1); RPS6KA2 (ribosomal protein S6 kinase A2); and RPS6KA3 (ribosomal protein S6 kinase A3). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See rskn-1 in Genome Data Viewer
    Location:
    chromosome: I
    Exon count:
    15
    Sequence:
    Chromosome: I; NC_003279.8 (8573852..8580205, complement)

    Chromosome I - NC_003279.8Genomic Context describing neighboring genes Neighboring gene LSDAT_euk domain-containing protein;Transient receptor potential channel Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene L-serine ammonia-lyase Neighboring gene Smad protein daf-8 Neighboring gene putative nuclear transport factor 2

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003279.8

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. The Ras-ERK MAPK regulatory network controls dedifferentiation in Caenorhabditis elegans germline. Cha DS, et al. Biochim Biophys Acta, 2012 Oct. PMID 22820175
    2. d-Serine and d-Alanine Regulate Adaptive Foraging Behavior in Caenorhabditis elegans via the NMDA Receptor. Saitoh Y, et al. J Neurosci, 2020 Sep 23. PMID 32855271, Free PMC Article
    3. eIF4E function in somatic cells modulates ageing in Caenorhabditis elegans. Syntichaki P, et al. Nature, 2007 Feb 22. PMID 17277769
    4. Multiple ERK substrates execute single biological processes in Caenorhabditis elegans germ-line development. Arur S, et al. Proc Natl Acad Sci U S A, 2009 Mar 24. PMID 19264959, Free PMC Article
    5. LIN-41 and OMA Ribonucleoprotein Complexes Mediate a Translational Repression-to-Activation Switch Controlling Oocyte Meiotic Maturation and the Oocyte-to-Embryo Transition in Caenorhabditis elegans. Tsukamoto T, et al. Genetics, 2017 Aug. PMID 28576864, Free PMC Article

    See all (11) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables magnesium ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein serine kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein serine/threonine kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables ribosomal protein S6 kinase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in TORC1 signaling IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    NOT involved_in determination of adult lifespan IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in intracellular signal transduction IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in protein phosphorylation IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in nucleoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    Putative ribosomal protein S6 kinase alpha-1;Ribosomal protein S6 kinase
    NP_001021602.1
    • Confirmed by transcript evidence
    NP_001021603.1
    • Confirmed by transcript evidence
    NP_001122504.1
    • Confirmed by transcript evidence
    NP_001379180.1
    • Confirmed by transcript evidence
    NP_492319.2
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003279.8 Reference assembly

      Range
      8573852..8580205 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_059918.4 → NP_492319.2  Putative ribosomal protein S6 kinase alpha-1 [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_492319.2

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q21734, Q58A96, Q7YSN4, Q93972, Q93973
      Conserved Domains (3) summary
      smart00220
      Location:104 → 363
      S_TKc; Serine/Threonine protein kinases, catalytic domain
      cd05582
      Location:108 → 424
      STKc_RSK_N; N-terminal catalytic domain of the Serine/Threonine Kinase, 90 kDa ribosomal protein S6 kinase
      cd14091
      Location:453 → 748
      STKc_RSK_C; C-terminal catalytic domain of the Serine/Threonine Kinases, Ribosomal S6 kinases

    2. NM_001026431.3 → NP_001021602.1  Putative ribosomal protein S6 kinase alpha-1 [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_001021602.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q21734
      Conserved Domains (3) summary
      smart00220
      Location:65 → 324
      S_TKc; Serine/Threonine protein kinases, catalytic domain
      cd05582
      Location:69 → 385
      STKc_RSK_N; N-terminal catalytic domain of the Serine/Threonine Kinase, 90 kDa ribosomal protein S6 kinase
      cd14091
      Location:414 → 709
      STKc_RSK_C; C-terminal catalytic domain of the Serine/Threonine Kinases, Ribosomal S6 kinases

    3. NM_001392686.1 → NP_001379180.1  Putative ribosomal protein S6 kinase alpha-1 [Caenorhabditis elegans]

      Status: REVIEWED

      Conserved Domains (2) summary
      cd05582
      Location:51 → 367
      STKc_RSK_N; N-terminal catalytic domain of the Serine/Threonine Kinase, 90 kDa ribosomal protein S6 kinase
      cd14091
      Location:396 → 691
      STKc_RSK_C; C-terminal catalytic domain of the Serine/Threonine Kinases, Ribosomal S6 kinases

    4. NM_001129032.5 → NP_001122504.1  Ribosomal protein S6 kinase [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_001122504.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      G5EE78
      Conserved Domains (3) summary
      smart00220
      Location:98 → 357
      S_TKc; Serine/Threonine protein kinases, catalytic domain
      cd05582
      Location:102 → 418
      STKc_RSK_N; N-terminal catalytic domain of the Serine/Threonine Kinase, 90 kDa ribosomal protein S6 kinase
      cd14091
      Location:447 → 744
      STKc_RSK_C; C-terminal catalytic domain of the Serine/Threonine Kinases, Ribosomal S6 kinases

    5. NM_001026432.5 → NP_001021603.1  Putative ribosomal protein S6 kinase alpha-1 [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_001021603.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q21734
      Conserved Domains (3) summary
      smart00220
      Location:85 → 344
      S_TKc; Serine/Threonine protein kinases, catalytic domain
      cd05582
      Location:89 → 405
      STKc_RSK_N; N-terminal catalytic domain of the Serine/Threonine Kinase, 90 kDa ribosomal protein S6 kinase
      cl21453
      Location:434 → 669
      PKc_like; Protein Kinases, catalytic domain
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q21734.4

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